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Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review

INTRODUCTION: Increased abdominal visceral adipose tissue (VAT) implies an adverse cardio-metabolic profile. We examined the association of abdominal VAT parameters and all-cause mortality risk. METHODS: We systematically searched four databases. We performed citations/articles screening, data abstr...

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Autores principales: Saad, Randa K., Ghezzawi, Malak, Horanieh, Renee, Khamis, Assem M., Saunders, Katherine H., Batsis, John A., Chakhtoura, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446237/
https://www.ncbi.nlm.nih.gov/pubmed/36082075
http://dx.doi.org/10.3389/fendo.2022.922931
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author Saad, Randa K.
Ghezzawi, Malak
Horanieh, Renee
Khamis, Assem M.
Saunders, Katherine H.
Batsis, John A.
Chakhtoura, Marlene
author_facet Saad, Randa K.
Ghezzawi, Malak
Horanieh, Renee
Khamis, Assem M.
Saunders, Katherine H.
Batsis, John A.
Chakhtoura, Marlene
author_sort Saad, Randa K.
collection PubMed
description INTRODUCTION: Increased abdominal visceral adipose tissue (VAT) implies an adverse cardio-metabolic profile. We examined the association of abdominal VAT parameters and all-cause mortality risk. METHODS: We systematically searched four databases. We performed citations/articles screening, data abstraction, and quality assessment in duplicate and independently (CRD42020205021). RESULTS: We included 12 cohorts, the majority used computed tomography to assess abdominal VAT area. Six cohorts with a mean age ≤ 65 years, examining all-cause mortality risk per increment in VAT area (cm(2)) or volume (cm(3)), showed a 11-98% relative risk increase with higher VAT parameters. However, the association lost significance after adjusting for glycemic indices, body mass index, or other fat parameters. In 4 cohorts with a mean age >65 years, the findings on mortality were inconsistent. Conversely, in two cohorts (mean age 73-77 years), a higher VAT density, was inversely proportional to VAT area, and implied a higher mortality risk. CONCLUSION: A high abdominal VAT area seems to be associated with increased all-cause mortality in individuals ≤ 65 years, possibly mediated by metabolic complications, and not through an independent effect. This relationship is weaker and may reverse in older individuals, most likely secondary to confounding bias and reverse causality. An individual participant data meta-analysis is needed to confirm our findings, and to define an abdominal VAT area cutoff implying increased mortality risk. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=205021, identifier CRD42020205021.
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spelling pubmed-94462372022-09-07 Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review Saad, Randa K. Ghezzawi, Malak Horanieh, Renee Khamis, Assem M. Saunders, Katherine H. Batsis, John A. Chakhtoura, Marlene Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Increased abdominal visceral adipose tissue (VAT) implies an adverse cardio-metabolic profile. We examined the association of abdominal VAT parameters and all-cause mortality risk. METHODS: We systematically searched four databases. We performed citations/articles screening, data abstraction, and quality assessment in duplicate and independently (CRD42020205021). RESULTS: We included 12 cohorts, the majority used computed tomography to assess abdominal VAT area. Six cohorts with a mean age ≤ 65 years, examining all-cause mortality risk per increment in VAT area (cm(2)) or volume (cm(3)), showed a 11-98% relative risk increase with higher VAT parameters. However, the association lost significance after adjusting for glycemic indices, body mass index, or other fat parameters. In 4 cohorts with a mean age >65 years, the findings on mortality were inconsistent. Conversely, in two cohorts (mean age 73-77 years), a higher VAT density, was inversely proportional to VAT area, and implied a higher mortality risk. CONCLUSION: A high abdominal VAT area seems to be associated with increased all-cause mortality in individuals ≤ 65 years, possibly mediated by metabolic complications, and not through an independent effect. This relationship is weaker and may reverse in older individuals, most likely secondary to confounding bias and reverse causality. An individual participant data meta-analysis is needed to confirm our findings, and to define an abdominal VAT area cutoff implying increased mortality risk. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=205021, identifier CRD42020205021. Frontiers Media S.A. 2022-08-22 /pmc/articles/PMC9446237/ /pubmed/36082075 http://dx.doi.org/10.3389/fendo.2022.922931 Text en Copyright © 2022 Saad, Ghezzawi, Horanieh, Khamis, Saunders, Batsis and Chakhtoura https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Saad, Randa K.
Ghezzawi, Malak
Horanieh, Renee
Khamis, Assem M.
Saunders, Katherine H.
Batsis, John A.
Chakhtoura, Marlene
Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review
title Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review
title_full Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review
title_fullStr Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review
title_full_unstemmed Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review
title_short Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review
title_sort abdominal visceral adipose tissue and all-cause mortality: a systematic review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446237/
https://www.ncbi.nlm.nih.gov/pubmed/36082075
http://dx.doi.org/10.3389/fendo.2022.922931
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