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Chloral Hydrate to Study Auditory Brainstem Response

Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems. AIM: To assess the efficacy of the drug in performing ABR and to systematize its use. MATERIALS AND METHODS: A prospective cross-section...

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Autores principales: Fávero, Mariana Lopes, Sanches Ponce, Fabiana Amaral, Barros Pio, Marcio Ricardo, Tabith, Alfredo, e Silva, Fernando Leite Carvalho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446251/
https://www.ncbi.nlm.nih.gov/pubmed/20835528
http://dx.doi.org/10.1590/S1808-86942010000400005
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author Fávero, Mariana Lopes
Sanches Ponce, Fabiana Amaral
Barros Pio, Marcio Ricardo
Tabith, Alfredo
e Silva, Fernando Leite Carvalho
author_facet Fávero, Mariana Lopes
Sanches Ponce, Fabiana Amaral
Barros Pio, Marcio Ricardo
Tabith, Alfredo
e Silva, Fernando Leite Carvalho
author_sort Fávero, Mariana Lopes
collection PubMed
description Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems. AIM: To assess the efficacy of the drug in performing ABR and to systematize its use. MATERIALS AND METHODS: A prospective cross-sectional study with 41 children without history of heart or lung disease. The initial dose of CH at 10% was 50mg/Kg, with a boost dose of 6mg/Kg administered 30 minutes later in cases in which there was no sedation. Drug effectiveness was established by sleep induction by 1 hour after the administration of the initial dose. Sleep occurrence was correlated with doses (50mg or 56mg/Kg), age, weight and gender. RESULTS: All the 41 children who participated in the study took 50mg/kgof the agent and 23 of them slept within 30 minutes, 2 had respiratory complications, 16 had the 6mg/Kg boost dose and 13 fell asleep after 30 minutes. The 56 mg/kg dose presented a statistically significant effect on sleep induction (p<0.05) when compared to the 50mg/kg dose. CONCLUSION: CH produced a satisfactory effect with 50 mg/Kg dose plus 6mg/kg up to one hour after administration. Complications can occur regardless of the dose used.
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spelling pubmed-94462512022-09-09 Chloral Hydrate to Study Auditory Brainstem Response Fávero, Mariana Lopes Sanches Ponce, Fabiana Amaral Barros Pio, Marcio Ricardo Tabith, Alfredo e Silva, Fernando Leite Carvalho Braz J Otorhinolaryngol Original Article Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems. AIM: To assess the efficacy of the drug in performing ABR and to systematize its use. MATERIALS AND METHODS: A prospective cross-sectional study with 41 children without history of heart or lung disease. The initial dose of CH at 10% was 50mg/Kg, with a boost dose of 6mg/Kg administered 30 minutes later in cases in which there was no sedation. Drug effectiveness was established by sleep induction by 1 hour after the administration of the initial dose. Sleep occurrence was correlated with doses (50mg or 56mg/Kg), age, weight and gender. RESULTS: All the 41 children who participated in the study took 50mg/kgof the agent and 23 of them slept within 30 minutes, 2 had respiratory complications, 16 had the 6mg/Kg boost dose and 13 fell asleep after 30 minutes. The 56 mg/kg dose presented a statistically significant effect on sleep induction (p<0.05) when compared to the 50mg/kg dose. CONCLUSION: CH produced a satisfactory effect with 50 mg/Kg dose plus 6mg/kg up to one hour after administration. Complications can occur regardless of the dose used. Elsevier 2015-10-19 /pmc/articles/PMC9446251/ /pubmed/20835528 http://dx.doi.org/10.1590/S1808-86942010000400005 Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Fávero, Mariana Lopes
Sanches Ponce, Fabiana Amaral
Barros Pio, Marcio Ricardo
Tabith, Alfredo
e Silva, Fernando Leite Carvalho
Chloral Hydrate to Study Auditory Brainstem Response
title Chloral Hydrate to Study Auditory Brainstem Response
title_full Chloral Hydrate to Study Auditory Brainstem Response
title_fullStr Chloral Hydrate to Study Auditory Brainstem Response
title_full_unstemmed Chloral Hydrate to Study Auditory Brainstem Response
title_short Chloral Hydrate to Study Auditory Brainstem Response
title_sort chloral hydrate to study auditory brainstem response
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446251/
https://www.ncbi.nlm.nih.gov/pubmed/20835528
http://dx.doi.org/10.1590/S1808-86942010000400005
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