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Chloral Hydrate to Study Auditory Brainstem Response
Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems. AIM: To assess the efficacy of the drug in performing ABR and to systematize its use. MATERIALS AND METHODS: A prospective cross-section...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446251/ https://www.ncbi.nlm.nih.gov/pubmed/20835528 http://dx.doi.org/10.1590/S1808-86942010000400005 |
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author | Fávero, Mariana Lopes Sanches Ponce, Fabiana Amaral Barros Pio, Marcio Ricardo Tabith, Alfredo e Silva, Fernando Leite Carvalho |
author_facet | Fávero, Mariana Lopes Sanches Ponce, Fabiana Amaral Barros Pio, Marcio Ricardo Tabith, Alfredo e Silva, Fernando Leite Carvalho |
author_sort | Fávero, Mariana Lopes |
collection | PubMed |
description | Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems. AIM: To assess the efficacy of the drug in performing ABR and to systematize its use. MATERIALS AND METHODS: A prospective cross-sectional study with 41 children without history of heart or lung disease. The initial dose of CH at 10% was 50mg/Kg, with a boost dose of 6mg/Kg administered 30 minutes later in cases in which there was no sedation. Drug effectiveness was established by sleep induction by 1 hour after the administration of the initial dose. Sleep occurrence was correlated with doses (50mg or 56mg/Kg), age, weight and gender. RESULTS: All the 41 children who participated in the study took 50mg/kgof the agent and 23 of them slept within 30 minutes, 2 had respiratory complications, 16 had the 6mg/Kg boost dose and 13 fell asleep after 30 minutes. The 56 mg/kg dose presented a statistically significant effect on sleep induction (p<0.05) when compared to the 50mg/kg dose. CONCLUSION: CH produced a satisfactory effect with 50 mg/Kg dose plus 6mg/kg up to one hour after administration. Complications can occur regardless of the dose used. |
format | Online Article Text |
id | pubmed-9446251 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94462512022-09-09 Chloral Hydrate to Study Auditory Brainstem Response Fávero, Mariana Lopes Sanches Ponce, Fabiana Amaral Barros Pio, Marcio Ricardo Tabith, Alfredo e Silva, Fernando Leite Carvalho Braz J Otorhinolaryngol Original Article Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems. AIM: To assess the efficacy of the drug in performing ABR and to systematize its use. MATERIALS AND METHODS: A prospective cross-sectional study with 41 children without history of heart or lung disease. The initial dose of CH at 10% was 50mg/Kg, with a boost dose of 6mg/Kg administered 30 minutes later in cases in which there was no sedation. Drug effectiveness was established by sleep induction by 1 hour after the administration of the initial dose. Sleep occurrence was correlated with doses (50mg or 56mg/Kg), age, weight and gender. RESULTS: All the 41 children who participated in the study took 50mg/kgof the agent and 23 of them slept within 30 minutes, 2 had respiratory complications, 16 had the 6mg/Kg boost dose and 13 fell asleep after 30 minutes. The 56 mg/kg dose presented a statistically significant effect on sleep induction (p<0.05) when compared to the 50mg/kg dose. CONCLUSION: CH produced a satisfactory effect with 50 mg/Kg dose plus 6mg/kg up to one hour after administration. Complications can occur regardless of the dose used. Elsevier 2015-10-19 /pmc/articles/PMC9446251/ /pubmed/20835528 http://dx.doi.org/10.1590/S1808-86942010000400005 Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Fávero, Mariana Lopes Sanches Ponce, Fabiana Amaral Barros Pio, Marcio Ricardo Tabith, Alfredo e Silva, Fernando Leite Carvalho Chloral Hydrate to Study Auditory Brainstem Response |
title | Chloral Hydrate to Study Auditory Brainstem Response |
title_full | Chloral Hydrate to Study Auditory Brainstem Response |
title_fullStr | Chloral Hydrate to Study Auditory Brainstem Response |
title_full_unstemmed | Chloral Hydrate to Study Auditory Brainstem Response |
title_short | Chloral Hydrate to Study Auditory Brainstem Response |
title_sort | chloral hydrate to study auditory brainstem response |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446251/ https://www.ncbi.nlm.nih.gov/pubmed/20835528 http://dx.doi.org/10.1590/S1808-86942010000400005 |
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