Molecular mechanisms and physiological functions of autophagy in kidney diseases

Autophagy is a highly conserved cellular progress for the degradation of cytoplasmic contents including micromolecules, misfolded proteins, and damaged organelles that has recently captured attention in kidney diseases. Basal autophagy plays a pivotal role in maintaining cell survival and kidney hom...

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Autores principales: Yang, Jingchao, Yuan, Longhui, Liu, Fei, Li, Lan, Liu, Jingping, Chen, Younan, Lu, Yanrong, Yuan, Yujia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446454/
https://www.ncbi.nlm.nih.gov/pubmed/36081940
http://dx.doi.org/10.3389/fphar.2022.974829
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author Yang, Jingchao
Yuan, Longhui
Liu, Fei
Li, Lan
Liu, Jingping
Chen, Younan
Lu, Yanrong
Yuan, Yujia
author_facet Yang, Jingchao
Yuan, Longhui
Liu, Fei
Li, Lan
Liu, Jingping
Chen, Younan
Lu, Yanrong
Yuan, Yujia
author_sort Yang, Jingchao
collection PubMed
description Autophagy is a highly conserved cellular progress for the degradation of cytoplasmic contents including micromolecules, misfolded proteins, and damaged organelles that has recently captured attention in kidney diseases. Basal autophagy plays a pivotal role in maintaining cell survival and kidney homeostasis. Accordingly, dysregulation of autophagy has implicated in the pathologies of kidney diseases. In this review, we summarize the multifaceted role of autophagy in kidney aging, maladaptive repair, tubulointerstitial fibrosis and discuss autophagy-related drugs in kidney diseases. However, uncertainty still remains as to the precise mechanisms of autophagy in kidney diseases. Further research is needed to clarify the accurate molecular mechanism of autophagy in kidney diseases, which will facilitate the discovery of a promising strategy for the prevention and treatment of kidney diseases.
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spelling pubmed-94464542022-09-07 Molecular mechanisms and physiological functions of autophagy in kidney diseases Yang, Jingchao Yuan, Longhui Liu, Fei Li, Lan Liu, Jingping Chen, Younan Lu, Yanrong Yuan, Yujia Front Pharmacol Pharmacology Autophagy is a highly conserved cellular progress for the degradation of cytoplasmic contents including micromolecules, misfolded proteins, and damaged organelles that has recently captured attention in kidney diseases. Basal autophagy plays a pivotal role in maintaining cell survival and kidney homeostasis. Accordingly, dysregulation of autophagy has implicated in the pathologies of kidney diseases. In this review, we summarize the multifaceted role of autophagy in kidney aging, maladaptive repair, tubulointerstitial fibrosis and discuss autophagy-related drugs in kidney diseases. However, uncertainty still remains as to the precise mechanisms of autophagy in kidney diseases. Further research is needed to clarify the accurate molecular mechanism of autophagy in kidney diseases, which will facilitate the discovery of a promising strategy for the prevention and treatment of kidney diseases. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9446454/ /pubmed/36081940 http://dx.doi.org/10.3389/fphar.2022.974829 Text en Copyright © 2022 Yang, Yuan, Liu, Li, Liu, Chen, Lu and Yuan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yang, Jingchao
Yuan, Longhui
Liu, Fei
Li, Lan
Liu, Jingping
Chen, Younan
Lu, Yanrong
Yuan, Yujia
Molecular mechanisms and physiological functions of autophagy in kidney diseases
title Molecular mechanisms and physiological functions of autophagy in kidney diseases
title_full Molecular mechanisms and physiological functions of autophagy in kidney diseases
title_fullStr Molecular mechanisms and physiological functions of autophagy in kidney diseases
title_full_unstemmed Molecular mechanisms and physiological functions of autophagy in kidney diseases
title_short Molecular mechanisms and physiological functions of autophagy in kidney diseases
title_sort molecular mechanisms and physiological functions of autophagy in kidney diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446454/
https://www.ncbi.nlm.nih.gov/pubmed/36081940
http://dx.doi.org/10.3389/fphar.2022.974829
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