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Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency

BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder most commonly secondary to a single mutation in the SERPINA1 gene (PI*Z) that causes misfolding and accumulation of alpha-1 antitrypsin (AAT) in hepatocytes and mononuclear phagocytes which reduces plasma AAT and creates a toxic...

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Detalles Bibliográficos
Autores principales:	Khodayari, Nazli, Oshins, Regina, Mehrad, Borna, Lascano, Jorge E., Qiang, Xiao, West, Jesse R., Holliday, L. Shannon, Lee, Jungnam, Wiesemann, Gayle, Eydgahi, Soroush, Brantly, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446525/ https://www.ncbi.nlm.nih.gov/pubmed/36068572 http://dx.doi.org/10.1186/s12931-022-02161-z

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