The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways

Interleukin-1 receptor-associated kinases (IRAKs) −4, −2, and −1 are involved in transducing signals from Toll-like receptors (TLRs) via the adaptor myeloid differentiation primary-response protein 88 (MYD88). How MYD88/IRAK4/2/1 complexes are formed, their redundancies, and potential non-enzymatic...

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Detalles Bibliográficos
Autores principales: Pereira, Milton, Durso, Danielle F., Bryant, Clare E., Kurt-Jones, Evelyn A., Silverman, Neal, Golenbock, Douglas T., Gazzinelli, Ricardo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446533/
https://www.ncbi.nlm.nih.gov/pubmed/35977521
http://dx.doi.org/10.1016/j.celrep.2022.111225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446533/
https://www.ncbi.nlm.nih.gov/pubmed/35977521
http://dx.doi.org/10.1016/j.celrep.2022.111225

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