Cargando…

The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways

Interleukin-1 receptor-associated kinases (IRAKs) −4, −2, and −1 are involved in transducing signals from Toll-like receptors (TLRs) via the adaptor myeloid differentiation primary-response protein 88 (MYD88). How MYD88/IRAK4/2/1 complexes are formed, their redundancies, and potential non-enzymatic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pereira, Milton, Durso, Danielle F., Bryant, Clare E., Kurt-Jones, Evelyn A., Silverman, Neal, Golenbock, Douglas T., Gazzinelli, Ricardo T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446533/ https://www.ncbi.nlm.nih.gov/pubmed/35977521 http://dx.doi.org/10.1016/j.celrep.2022.111225

Ejemplares similares

Helical assembly in the MyD88:IRAK4:IRAK2 complex in TLR/IL-1R signaling
por: Lin, Su-Chang, et al.
Publicado: (2010)

IRAK4 inhibition to shut down TLR signaling in autoimmunity and MyD88-dependent lymphomas
por: Küppers, Ralf
Publicado: (2015)

Expressions of TLR4, MyD88, IRAK4 and NF-ÎB in the oviduct of Chinese brown frog (Rana dybowskii)
por: Zhang, Yue, et al.
Publicado: (2019)

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
por: Lin, Sen, et al.
Publicado: (2012)

Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways
por: Pang, Zheng, et al.
Publicado: (2018)

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88
por: Sakai, Jiro, et al.
Publicado: (2017)

Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish
por: Srivastava, Nidhi, et al.
Publicado: (2017)

Experimental and natural infections in MyD88‐ and IRAK‐4‐deficient mice and humans
por: von Bernuth, Horst, et al.
Publicado: (2012)

Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly
por: George, Julie, et al.
Publicado: (2011)

Beyond MyD88 and TRIF Pathways in Toll-Like Receptor Signaling
por: Piras, Vincent, et al.
Publicado: (2014)

Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer
por: Chuffa, Luiz Gustavo A, et al.
Publicado: (2015)

Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice
por: Heuss, Neal D, et al.
Publicado: (2014)

MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis
por: Yang, Du-Jiang, et al.
Publicado: (2022)

Downregulation of Paralemmin-3 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Rats by Regulating Inflammatory Response and Inhibiting Formation of TLR4/MyD88 and TLR4/TRIF Complexes
por: Chen, Xuxin, et al.
Publicado: (2017)

Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
por: García-García, Ana, et al.
Publicado: (2023)

Surface immunogenic protein from Streptococcus agalactiae and Fissurella latimarginata hemocyanin are TLR4 ligands and activate MyD88- and TRIF dependent signaling pathways
por: Díaz-Dinamarca, Diego A., et al.
Publicado: (2023)

The Expression of Plasmacytoid Dendritic Cells and TLR7/9-MyD88-IRAKs Pathway in Chronic Eczema Lesions
por: Wen, Jiamin, et al.
Publicado: (2023)

Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML
por: Bennett, Joshua, et al.
Publicado: (2023)

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer
por: Block, Matthew S., et al.
Publicado: (2018)

MyD88 and TRIF mediate divergent inflammatory and regenerative responses to skeletal muscle ischemia
por: Sachdev, Ulka, et al.
Publicado: (2014)

Induction of TRIF- or MYD88-dependent pathways perturbs cell cycle regulation in pancreatic cancer
por: Zambirinis, Constantinos P., et al.
Publicado: (2013)

Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes
por: Androulidaki, Ariadne, et al.
Publicado: (2018)

Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88- and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection
por: Karmakar, Joyshree, et al.
Publicado: (2021)

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts
por: Chen, Junbin, et al.
Publicado: (2020)

IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis
por: Thiel, Franziska G., et al.
Publicado: (2023)

A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway
por: Yoon, Sae-Bom, et al.
Publicado: (2023)

MyD88 But Not TRIF Is Essential for Osteoclastogenesis Induced by Lipopolysaccharide, Diacyl Lipopeptide, and IL-1α
por: Sato, Nobuaki, et al.
Publicado: (2004)

Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88
por: Zhang, Huajia, et al.
Publicado: (2016)

Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis
por: Pan, Xiao, et al.
Publicado: (2022)

Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF
por: Semple, Fiona, et al.
Publicado: (2011)

Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection
por: Kirsebom, Freja C. M., et al.
Publicado: (2019)

Invasive group A Streptococcus disease in French-Canadian children is not associated with a defect in MyD88/IRAK4-pathway
por: Fernandez, Isabel, et al.
Publicado: (2014)

Rare Variants in MYD88, IRAK4 and IKBKG and Susceptibility to Invasive Pneumococcal Disease: A Population-Based Case-Control Study
por: Ellis, Magda K., et al.
Publicado: (2015)

Regulation of innate immune signaling by IRAK proteins
por: Pereira, Milton, et al.
Publicado: (2023)

Mechanism of focal cerebral ischemic tolerance in rats with ischemic preconditioning involves MyD88- and TRIF-dependent pathways
por: LI, HAN, et al.
Publicado: (2013)

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
por: Fitzgerald, Katherine A., et al.
Publicado: (2003)

Mmm-derived lipid-associated membrane proteins activate IL-1β production through the NF-κB pathway via TLR2, MyD88, and IRAK4
por: Wang, Yang, et al.
Publicado: (2017)

Expression and significance of the TLR4/MyD88 signaling pathway in ovarian epithelial cancers
por: Kim, Ki Hyung, et al.
Publicado: (2012)

TLR4/MyD88 signaling determines the metastatic potential of breast cancer cells
por: Wu, Kunlin, et al.
Publicado: (2018)

DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway
por: Tsai, Su-Yu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_icca9f0fb8ah3sumd07vbe27ii