Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells

OBJECTIVE: Osteopontin (OPN) is a well-known glycoprotein involved in numerous pathobiological processes, including cancer. Despite having five splice variants for osteopontin in mice, the main focus of most studies has been on total OPN (tOPN). There are some studies on other splice variants, but t...

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Autores principales: Kamalabadi-Farahani, Mohammad, Atashi, Amir, Jabbarpour, Zahra, Aghayan, Seyed Sajjad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446537/
https://www.ncbi.nlm.nih.gov/pubmed/36064446
http://dx.doi.org/10.1186/s13104-022-06179-w
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author Kamalabadi-Farahani, Mohammad
Atashi, Amir
Jabbarpour, Zahra
Aghayan, Seyed Sajjad
author_facet Kamalabadi-Farahani, Mohammad
Atashi, Amir
Jabbarpour, Zahra
Aghayan, Seyed Sajjad
author_sort Kamalabadi-Farahani, Mohammad
collection PubMed
description OBJECTIVE: Osteopontin (OPN) is a well-known glycoprotein involved in numerous pathobiological processes, including cancer. Despite having five splice variants for osteopontin in mice, the main focus of most studies has been on total OPN (tOPN). There are some studies on other splice variants, but the expression of osteopontin-5 (OPN5) has not been addressed in mouse cancer cells. Therefore, this study sought to evaluate OPN5 expression in mouse breast cancer cells. RESULTS: The expression of OPN5 in primary and metastatic breast cancer cells of mice was confirmed in our study. These findings provided important insights regarding the OPN alternative splicing in mice for the first time. It is concluded that, like other OPN-SVs, OPN5 probably plays an essential role in tumor progression, which requires further investigation in different tumor models.
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spelling pubmed-94465372022-09-07 Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells Kamalabadi-Farahani, Mohammad Atashi, Amir Jabbarpour, Zahra Aghayan, Seyed Sajjad BMC Res Notes Research Note OBJECTIVE: Osteopontin (OPN) is a well-known glycoprotein involved in numerous pathobiological processes, including cancer. Despite having five splice variants for osteopontin in mice, the main focus of most studies has been on total OPN (tOPN). There are some studies on other splice variants, but the expression of osteopontin-5 (OPN5) has not been addressed in mouse cancer cells. Therefore, this study sought to evaluate OPN5 expression in mouse breast cancer cells. RESULTS: The expression of OPN5 in primary and metastatic breast cancer cells of mice was confirmed in our study. These findings provided important insights regarding the OPN alternative splicing in mice for the first time. It is concluded that, like other OPN-SVs, OPN5 probably plays an essential role in tumor progression, which requires further investigation in different tumor models. BioMed Central 2022-09-05 /pmc/articles/PMC9446537/ /pubmed/36064446 http://dx.doi.org/10.1186/s13104-022-06179-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Kamalabadi-Farahani, Mohammad
Atashi, Amir
Jabbarpour, Zahra
Aghayan, Seyed Sajjad
Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells
title Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells
title_full Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells
title_fullStr Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells
title_full_unstemmed Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells
title_short Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells
title_sort expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446537/
https://www.ncbi.nlm.nih.gov/pubmed/36064446
http://dx.doi.org/10.1186/s13104-022-06179-w
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AT atashiamir expressionofosteopontin5splicevariantinthemouseprimaryandmetastaticbreastcancercells
AT jabbarpourzahra expressionofosteopontin5splicevariantinthemouseprimaryandmetastaticbreastcancercells
AT aghayanseyedsajjad expressionofosteopontin5splicevariantinthemouseprimaryandmetastaticbreastcancercells

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