The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots

BACKGROUND: The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination hotspots in mammals. Beyond histone methylation, H3 lysine 9 acetylation (H3K9ac) is also greatly enriched at recombination hotspots. Previous work has ind...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Shenli, Huang, Tao, Bao, Ziyou, Wang, Shiyu, Wu, Xinyue, Liu, Jiang, Liu, Hongbin, Chen, Zi-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446545/
https://www.ncbi.nlm.nih.gov/pubmed/36068616
http://dx.doi.org/10.1186/s13059-022-02758-z

Ejemplares similares

Ejemplares similares