Genomic surveillance of SARS-CoV-2 Omicron variants on a university campus

Novel variants continue to emerge in the SARS-CoV-2 pandemic. University testing programs may provide timely epidemiologic and genomic surveillance data to inform public health responses. We conducted testing from September 2021 to February 2022 in a university population under vaccination and indoo...

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Detalles Bibliográficos
Autores principales: Weil, Ana A., Luiten, Kyle G., Casto, Amanda M., Bennett, Julia C., O’Hanlon, Jessica, Han, Peter D., Gamboa, Luis S., McDermot, Evan, Truong, Melissa, Gottlieb, Geoffrey S., Acker, Zack, Wolf, Caitlin R., Magedson, Ariana, Chow, Eric J., Lo, Natalie K., Pothan, Lincoln C., McDonald, Devon, Wright, Tessa C., McCaffrey, Kathryn M., Figgins, Marlin D., Englund, Janet A., Boeckh, Michael, Lockwood, Christina M., Nickerson, Deborah A., Shendure, Jay, Bedford, Trevor, Hughes, James P., Starita, Lea M., Chu, Helen Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446629/
https://www.ncbi.nlm.nih.gov/pubmed/36068236
http://dx.doi.org/10.1038/s41467-022-32786-z
Descripción
Sumario:Novel variants continue to emerge in the SARS-CoV-2 pandemic. University testing programs may provide timely epidemiologic and genomic surveillance data to inform public health responses. We conducted testing from September 2021 to February 2022 in a university population under vaccination and indoor mask mandates. A total of 3,048 of 24,393 individuals tested positive for SARS-CoV-2 by RT-PCR; whole genome sequencing identified 209 Delta and 1,730 Omicron genomes of the 1,939 total sequenced. Compared to Delta, Omicron had a shorter median serial interval between genetically identical, symptomatic infections within households (2 versus 6 days, P = 0.021). Omicron also demonstrated a greater peak reproductive number (2.4 versus 1.8), and a 1.07 (95% confidence interval: 0.58, 1.57; P < 0.0001) higher mean cycle threshold value. Despite near universal vaccination and stringent mitigation measures, Omicron rapidly displaced the Delta variant to become the predominant viral strain and led to a surge in cases in a university population.

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