Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria

BACKGROUND: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. METHODS: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryo...

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Autores principales: Leonardo, Leo, Kenangalem, Enny, Poespoprodjo, Jeanne R., Noviyanti, Rintis, Price, Ric N., Anstey, Nicholas M., Minigo, Gabriela, Kho, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446641/
https://www.ncbi.nlm.nih.gov/pubmed/36068577
http://dx.doi.org/10.1186/s12936-022-04268-6
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author Leonardo, Leo
Kenangalem, Enny
Poespoprodjo, Jeanne R.
Noviyanti, Rintis
Price, Ric N.
Anstey, Nicholas M.
Minigo, Gabriela
Kho, Steven
author_facet Leonardo, Leo
Kenangalem, Enny
Poespoprodjo, Jeanne R.
Noviyanti, Rintis
Price, Ric N.
Anstey, Nicholas M.
Minigo, Gabriela
Kho, Steven
author_sort Leonardo, Leo
collection PubMed
description BACKGROUND: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. METHODS: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia. RESULTS: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria. CONCLUSION: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.
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spelling pubmed-94466412022-09-06 Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria Leonardo, Leo Kenangalem, Enny Poespoprodjo, Jeanne R. Noviyanti, Rintis Price, Ric N. Anstey, Nicholas M. Minigo, Gabriela Kho, Steven Malar J Research BACKGROUND: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. METHODS: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia. RESULTS: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria. CONCLUSION: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria. BioMed Central 2022-09-06 /pmc/articles/PMC9446641/ /pubmed/36068577 http://dx.doi.org/10.1186/s12936-022-04268-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Leonardo, Leo
Kenangalem, Enny
Poespoprodjo, Jeanne R.
Noviyanti, Rintis
Price, Ric N.
Anstey, Nicholas M.
Minigo, Gabriela
Kho, Steven
Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
title Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
title_full Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
title_fullStr Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
title_full_unstemmed Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
title_short Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
title_sort increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446641/
https://www.ncbi.nlm.nih.gov/pubmed/36068577
http://dx.doi.org/10.1186/s12936-022-04268-6
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