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The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Science China Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446657/ https://www.ncbi.nlm.nih.gov/pubmed/36066811 http://dx.doi.org/10.1007/s11427-022-2161-3 |
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| author | Cai, Yusheng Song, Wei Li, Jiaming Jing, Ying Liang, Chuqian Zhang, Liyuan Zhang, Xia Zhang, Wenhui Liu, Beibei An, Yongpan Li, Jingyi Tang, Baixue Pei, Siyu Wu, Xueying Liu, Yuxuan Zhuang, Cheng-Le Ying, Yilin Dou, Xuefeng Chen, Yu Xiao, Fu-Hui Li, Dingfeng Yang, Ruici Zhao, Ya Wang, Yang Wang, Lihui Li, Yujing Ma, Shuai Wang, Si Song, Xiaoyuan Ren, Jie Zhang, Liang Wang, Jun Zhang, Weiqi Xie, Zhengwei Qu, Jing Wang, Jianwei Xiao, Yichuan Tian, Ye Wang, Gelin Hu, Ping Ye, Jing Sun, Yu Mao, Zhiyong Kong, Qing-Peng Liu, Qiang Zou, Weiguo Tian, Xiao-Li Xiao, Zhi-Xiong Liu, Yong Liu, Jun-Ping Song, Moshi Han, Jing-Dong J. Liu, Guang-Hui |
| author_facet | Cai, Yusheng Song, Wei Li, Jiaming Jing, Ying Liang, Chuqian Zhang, Liyuan Zhang, Xia Zhang, Wenhui Liu, Beibei An, Yongpan Li, Jingyi Tang, Baixue Pei, Siyu Wu, Xueying Liu, Yuxuan Zhuang, Cheng-Le Ying, Yilin Dou, Xuefeng Chen, Yu Xiao, Fu-Hui Li, Dingfeng Yang, Ruici Zhao, Ya Wang, Yang Wang, Lihui Li, Yujing Ma, Shuai Wang, Si Song, Xiaoyuan Ren, Jie Zhang, Liang Wang, Jun Zhang, Weiqi Xie, Zhengwei Qu, Jing Wang, Jianwei Xiao, Yichuan Tian, Ye Wang, Gelin Hu, Ping Ye, Jing Sun, Yu Mao, Zhiyong Kong, Qing-Peng Liu, Qiang Zou, Weiguo Tian, Xiao-Li Xiao, Zhi-Xiong Liu, Yong Liu, Jun-Ping Song, Moshi Han, Jing-Dong J. Liu, Guang-Hui |
| author_sort | Cai, Yusheng |
| collection | PubMed |
| description | Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels. |
| format | Online Article Text |
| id | pubmed-9446657 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Science China Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94466572022-09-06 The landscape of aging Cai, Yusheng Song, Wei Li, Jiaming Jing, Ying Liang, Chuqian Zhang, Liyuan Zhang, Xia Zhang, Wenhui Liu, Beibei An, Yongpan Li, Jingyi Tang, Baixue Pei, Siyu Wu, Xueying Liu, Yuxuan Zhuang, Cheng-Le Ying, Yilin Dou, Xuefeng Chen, Yu Xiao, Fu-Hui Li, Dingfeng Yang, Ruici Zhao, Ya Wang, Yang Wang, Lihui Li, Yujing Ma, Shuai Wang, Si Song, Xiaoyuan Ren, Jie Zhang, Liang Wang, Jun Zhang, Weiqi Xie, Zhengwei Qu, Jing Wang, Jianwei Xiao, Yichuan Tian, Ye Wang, Gelin Hu, Ping Ye, Jing Sun, Yu Mao, Zhiyong Kong, Qing-Peng Liu, Qiang Zou, Weiguo Tian, Xiao-Li Xiao, Zhi-Xiong Liu, Yong Liu, Jun-Ping Song, Moshi Han, Jing-Dong J. Liu, Guang-Hui Sci China Life Sci Review Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels. Science China Press 2022-09-02 2022 /pmc/articles/PMC9446657/ /pubmed/36066811 http://dx.doi.org/10.1007/s11427-022-2161-3 Text en © Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Review Cai, Yusheng Song, Wei Li, Jiaming Jing, Ying Liang, Chuqian Zhang, Liyuan Zhang, Xia Zhang, Wenhui Liu, Beibei An, Yongpan Li, Jingyi Tang, Baixue Pei, Siyu Wu, Xueying Liu, Yuxuan Zhuang, Cheng-Le Ying, Yilin Dou, Xuefeng Chen, Yu Xiao, Fu-Hui Li, Dingfeng Yang, Ruici Zhao, Ya Wang, Yang Wang, Lihui Li, Yujing Ma, Shuai Wang, Si Song, Xiaoyuan Ren, Jie Zhang, Liang Wang, Jun Zhang, Weiqi Xie, Zhengwei Qu, Jing Wang, Jianwei Xiao, Yichuan Tian, Ye Wang, Gelin Hu, Ping Ye, Jing Sun, Yu Mao, Zhiyong Kong, Qing-Peng Liu, Qiang Zou, Weiguo Tian, Xiao-Li Xiao, Zhi-Xiong Liu, Yong Liu, Jun-Ping Song, Moshi Han, Jing-Dong J. Liu, Guang-Hui The landscape of aging |
| title | The landscape of aging |
| title_full | The landscape of aging |
| title_fullStr | The landscape of aging |
| title_full_unstemmed | The landscape of aging |
| title_short | The landscape of aging |
| title_sort | landscape of aging |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446657/ https://www.ncbi.nlm.nih.gov/pubmed/36066811 http://dx.doi.org/10.1007/s11427-022-2161-3 |
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