Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts

BACKGROUND: EGFR targeting antibody-drug conjugates (ADCs) are highly effective against EGFR-amplified tumors, but poor distribution across the blood–brain barrier (BBB) limits their efficacy in glioblastoma (GBM) when administered systemically. We studied whether convection-enhanced delivery (CED)...

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Detalles Bibliográficos
Autores principales: Porath, Kendra A, Regan, Michael S, Griffith, Jessica I, Jain, Sonia, Stopka, Sylwia A, Burgenske, Danielle M, Bakken, Katrina K, Carlson, Brett L, Decker, Paul A, Vaubel, Rachael A, Dragojevic, Sonja, Mladek, Ann C, Connors, Margaret A, Hu, Zeng, He, Lihong, Kitange, Gaspar J, Gupta, Shiv K, Feldsien, Thomas M, Lefebvre, Didier R, Agar, Nathalie Y R, Eckel-Passow, Jeanette E, Reilly, Edward B, Elmquist, William F, Sarkaria, Jann N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446689/
https://www.ncbi.nlm.nih.gov/pubmed/36071925
http://dx.doi.org/10.1093/noajnl/vdac130

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