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The current status and future prospects for molecular imaging-guided precision surgery
Molecular imaging technologies are increasingly used to diagnose, monitor, and guide treatment of i.e., cancer. In this review, the current status and future prospects of the use of molecular imaging as an instrument to help realize precision surgery is addressed with focus on the main components th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446692/ https://www.ncbi.nlm.nih.gov/pubmed/36068619 http://dx.doi.org/10.1186/s40644-022-00482-2 |
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author | Boekestijn, Imke van Oosterom, Matthias N. Dell’Oglio, Paolo van Velden, Floris H. P. Pool, Martin Maurer, Tobias Rietbergen, Daphne D. D. Buckle, Tessa van Leeuwen, Fijs W. B. |
author_facet | Boekestijn, Imke van Oosterom, Matthias N. Dell’Oglio, Paolo van Velden, Floris H. P. Pool, Martin Maurer, Tobias Rietbergen, Daphne D. D. Buckle, Tessa van Leeuwen, Fijs W. B. |
author_sort | Boekestijn, Imke |
collection | PubMed |
description | Molecular imaging technologies are increasingly used to diagnose, monitor, and guide treatment of i.e., cancer. In this review, the current status and future prospects of the use of molecular imaging as an instrument to help realize precision surgery is addressed with focus on the main components that form the conceptual basis of intraoperative molecular imaging. Paramount for successful interventions is the relevance and accessibility of surgical targets. In addition, selection of the correct combination of imaging agents and modalities is critical to visualize both microscopic and bulk disease sites with high affinity and specificity. In this context developments within engineering/imaging physics continue to drive the growth of image-guided surgery. Particularly important herein is enhancement of sensitivity through improved contrast and spatial resolution, features that are critical if sites of cancer involvement are not to be overlooked during surgery. By facilitating the connection between surgical planning and surgical execution, digital surgery technologies such as computer-aided visualization nicely complement these technologies. The complexity of image guidance, combined with the plurality of technologies that are becoming available, also drives the need for evaluation mechanisms that can objectively score the impact that technologies exert on the performance of healthcare professionals and outcome improvement for patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40644-022-00482-2. |
format | Online Article Text |
id | pubmed-9446692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94466922022-09-07 The current status and future prospects for molecular imaging-guided precision surgery Boekestijn, Imke van Oosterom, Matthias N. Dell’Oglio, Paolo van Velden, Floris H. P. Pool, Martin Maurer, Tobias Rietbergen, Daphne D. D. Buckle, Tessa van Leeuwen, Fijs W. B. Cancer Imaging Review Molecular imaging technologies are increasingly used to diagnose, monitor, and guide treatment of i.e., cancer. In this review, the current status and future prospects of the use of molecular imaging as an instrument to help realize precision surgery is addressed with focus on the main components that form the conceptual basis of intraoperative molecular imaging. Paramount for successful interventions is the relevance and accessibility of surgical targets. In addition, selection of the correct combination of imaging agents and modalities is critical to visualize both microscopic and bulk disease sites with high affinity and specificity. In this context developments within engineering/imaging physics continue to drive the growth of image-guided surgery. Particularly important herein is enhancement of sensitivity through improved contrast and spatial resolution, features that are critical if sites of cancer involvement are not to be overlooked during surgery. By facilitating the connection between surgical planning and surgical execution, digital surgery technologies such as computer-aided visualization nicely complement these technologies. The complexity of image guidance, combined with the plurality of technologies that are becoming available, also drives the need for evaluation mechanisms that can objectively score the impact that technologies exert on the performance of healthcare professionals and outcome improvement for patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40644-022-00482-2. BioMed Central 2022-09-06 /pmc/articles/PMC9446692/ /pubmed/36068619 http://dx.doi.org/10.1186/s40644-022-00482-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Boekestijn, Imke van Oosterom, Matthias N. Dell’Oglio, Paolo van Velden, Floris H. P. Pool, Martin Maurer, Tobias Rietbergen, Daphne D. D. Buckle, Tessa van Leeuwen, Fijs W. B. The current status and future prospects for molecular imaging-guided precision surgery |
title | The current status and future prospects for molecular imaging-guided precision surgery |
title_full | The current status and future prospects for molecular imaging-guided precision surgery |
title_fullStr | The current status and future prospects for molecular imaging-guided precision surgery |
title_full_unstemmed | The current status and future prospects for molecular imaging-guided precision surgery |
title_short | The current status and future prospects for molecular imaging-guided precision surgery |
title_sort | current status and future prospects for molecular imaging-guided precision surgery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446692/ https://www.ncbi.nlm.nih.gov/pubmed/36068619 http://dx.doi.org/10.1186/s40644-022-00482-2 |
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