Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications

The current diagnosis and treatment of sarcoma continue to show limited timeliness and efficacy. In order to enable the early detection and management of sarcoma, increasing attentions have been given to the tumor microenvironment (TME). TME is a dynamic network composed of multiple cells, extracell...

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Autores principales: Ye, Huali, Hu, Xin, Wen, Yang, Tu, Chongqi, Hornicek, Francis, Duan, Zhenfeng, Min, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446729/
https://www.ncbi.nlm.nih.gov/pubmed/36064358
http://dx.doi.org/10.1186/s12951-022-01609-0
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author Ye, Huali
Hu, Xin
Wen, Yang
Tu, Chongqi
Hornicek, Francis
Duan, Zhenfeng
Min, Li
author_facet Ye, Huali
Hu, Xin
Wen, Yang
Tu, Chongqi
Hornicek, Francis
Duan, Zhenfeng
Min, Li
author_sort Ye, Huali
collection PubMed
description The current diagnosis and treatment of sarcoma continue to show limited timeliness and efficacy. In order to enable the early detection and management of sarcoma, increasing attentions have been given to the tumor microenvironment (TME). TME is a dynamic network composed of multiple cells, extracellular matrix, vasculature, and exosomes. Exosomes are nano-sized extracellular vesicles derived from various cells in the TME. The major function of exosomes is to promote cancer progress and metastasis through mediating bidirectional cellular communications between sarcoma cells and TME cells. Due to the content specificity, cell tropism, and bioavailability, exosomes have been regarded as promising diagnostic and prognostic biomarkers, and therapeutic vehicles for sarcoma. This review summarizes recent studies on the roles of exosomes in TME of sarcoma, and explores the emerging clinical applications.
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spelling pubmed-94467292022-09-07 Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications Ye, Huali Hu, Xin Wen, Yang Tu, Chongqi Hornicek, Francis Duan, Zhenfeng Min, Li J Nanobiotechnology Review The current diagnosis and treatment of sarcoma continue to show limited timeliness and efficacy. In order to enable the early detection and management of sarcoma, increasing attentions have been given to the tumor microenvironment (TME). TME is a dynamic network composed of multiple cells, extracellular matrix, vasculature, and exosomes. Exosomes are nano-sized extracellular vesicles derived from various cells in the TME. The major function of exosomes is to promote cancer progress and metastasis through mediating bidirectional cellular communications between sarcoma cells and TME cells. Due to the content specificity, cell tropism, and bioavailability, exosomes have been regarded as promising diagnostic and prognostic biomarkers, and therapeutic vehicles for sarcoma. This review summarizes recent studies on the roles of exosomes in TME of sarcoma, and explores the emerging clinical applications. BioMed Central 2022-09-05 /pmc/articles/PMC9446729/ /pubmed/36064358 http://dx.doi.org/10.1186/s12951-022-01609-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ye, Huali
Hu, Xin
Wen, Yang
Tu, Chongqi
Hornicek, Francis
Duan, Zhenfeng
Min, Li
Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications
title Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications
title_full Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications
title_fullStr Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications
title_full_unstemmed Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications
title_short Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications
title_sort exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446729/
https://www.ncbi.nlm.nih.gov/pubmed/36064358
http://dx.doi.org/10.1186/s12951-022-01609-0
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