Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury

Perinatal brain injury is a leading cause of death and disability in children. Hypoxic-ischemic encephalopathy in full term infants, and white matter injury in premature infants are most known brain injury in perinatal period. Human umbilical cord blood mononuclear cells contain hematopoietic stem c...

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Autores principales: Xi, Yufeng, Yue, Guang, Gao, Shuqiang, Ju, Rong, Wang, Yujia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446746/
https://www.ncbi.nlm.nih.gov/pubmed/36064459
http://dx.doi.org/10.1186/s13287-022-03153-y
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author Xi, Yufeng
Yue, Guang
Gao, Shuqiang
Ju, Rong
Wang, Yujia
author_facet Xi, Yufeng
Yue, Guang
Gao, Shuqiang
Ju, Rong
Wang, Yujia
author_sort Xi, Yufeng
collection PubMed
description Perinatal brain injury is a leading cause of death and disability in children. Hypoxic-ischemic encephalopathy in full term infants, and white matter injury in premature infants are most known brain injury in perinatal period. Human umbilical cord blood mononuclear cells contain hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, lymphocytes, monocytes, and so on. Human umbilical cord blood mononuclear cells have many biological functions, such as nerve and vascular regeneration, anti-apoptosis, anti-inflammation, and immune regulation. Human umbilical cord blood mononuclear cells transplantation has achieved significant efficacy and safety in animal and clinical trials for the treatment of perinatal brain injury. We will review human umbilical cord blood mononuclear cells transplantation for perinatal brain injury in this review.
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spelling pubmed-94467462022-09-07 Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury Xi, Yufeng Yue, Guang Gao, Shuqiang Ju, Rong Wang, Yujia Stem Cell Res Ther Review Perinatal brain injury is a leading cause of death and disability in children. Hypoxic-ischemic encephalopathy in full term infants, and white matter injury in premature infants are most known brain injury in perinatal period. Human umbilical cord blood mononuclear cells contain hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, lymphocytes, monocytes, and so on. Human umbilical cord blood mononuclear cells have many biological functions, such as nerve and vascular regeneration, anti-apoptosis, anti-inflammation, and immune regulation. Human umbilical cord blood mononuclear cells transplantation has achieved significant efficacy and safety in animal and clinical trials for the treatment of perinatal brain injury. We will review human umbilical cord blood mononuclear cells transplantation for perinatal brain injury in this review. BioMed Central 2022-09-05 /pmc/articles/PMC9446746/ /pubmed/36064459 http://dx.doi.org/10.1186/s13287-022-03153-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xi, Yufeng
Yue, Guang
Gao, Shuqiang
Ju, Rong
Wang, Yujia
Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury
title Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury
title_full Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury
title_fullStr Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury
title_full_unstemmed Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury
title_short Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury
title_sort human umbilical cord blood mononuclear cells transplantation for perinatal brain injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446746/
https://www.ncbi.nlm.nih.gov/pubmed/36064459
http://dx.doi.org/10.1186/s13287-022-03153-y
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