CD47 as a promising therapeutic target in oncology

CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular phagocytosis by macrophages, determines life span of individual erythrocytes, regulates activation of immune cells, and manipu...

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Autores principales: Zhao, Hai, Song, Shuangshuang, Ma, Junwei, Yan, Zhiyong, Xie, Hongwei, Feng, Ying, Che, Shusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446754/
https://www.ncbi.nlm.nih.gov/pubmed/36081498
http://dx.doi.org/10.3389/fimmu.2022.757480
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author Zhao, Hai
Song, Shuangshuang
Ma, Junwei
Yan, Zhiyong
Xie, Hongwei
Feng, Ying
Che, Shusheng
author_facet Zhao, Hai
Song, Shuangshuang
Ma, Junwei
Yan, Zhiyong
Xie, Hongwei
Feng, Ying
Che, Shusheng
author_sort Zhao, Hai
collection PubMed
description CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular phagocytosis by macrophages, determines life span of individual erythrocytes, regulates activation of immune cells, and manipulates synaptic pruning during neuronal development. As such, CD47 has recently be regarded as one of novel innate checkpoint receptor targets for cancer immunotherapy. In this review, we will discuss increasing awareness about the diverse functions of CD47 and its role in immune system homeostasis. Then, we will discuss its potential therapeutic roles against cancer and outlines, the possible future research directions of CD47- based therapeutics against cancer.
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spelling pubmed-94467542022-09-07 CD47 as a promising therapeutic target in oncology Zhao, Hai Song, Shuangshuang Ma, Junwei Yan, Zhiyong Xie, Hongwei Feng, Ying Che, Shusheng Front Immunol Immunology CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular phagocytosis by macrophages, determines life span of individual erythrocytes, regulates activation of immune cells, and manipulates synaptic pruning during neuronal development. As such, CD47 has recently be regarded as one of novel innate checkpoint receptor targets for cancer immunotherapy. In this review, we will discuss increasing awareness about the diverse functions of CD47 and its role in immune system homeostasis. Then, we will discuss its potential therapeutic roles against cancer and outlines, the possible future research directions of CD47- based therapeutics against cancer. Frontiers Media S.A. 2022-08-22 /pmc/articles/PMC9446754/ /pubmed/36081498 http://dx.doi.org/10.3389/fimmu.2022.757480 Text en Copyright © 2022 Zhao, Song, Ma, Yan, Xie, Feng and Che https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhao, Hai
Song, Shuangshuang
Ma, Junwei
Yan, Zhiyong
Xie, Hongwei
Feng, Ying
Che, Shusheng
CD47 as a promising therapeutic target in oncology
title CD47 as a promising therapeutic target in oncology
title_full CD47 as a promising therapeutic target in oncology
title_fullStr CD47 as a promising therapeutic target in oncology
title_full_unstemmed CD47 as a promising therapeutic target in oncology
title_short CD47 as a promising therapeutic target in oncology
title_sort cd47 as a promising therapeutic target in oncology
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446754/
https://www.ncbi.nlm.nih.gov/pubmed/36081498
http://dx.doi.org/10.3389/fimmu.2022.757480
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