Overestimation of benefit when clinical trials stop early: a simulation study

BACKGROUND: Stopping trials early because of a favourable interim analysis can exaggerate benefit. This study simulated trials typical of those stopping early for benefit in the real world and estimated the degree to which early stopping likely overestimates benefit. METHODS: From 1 million simulate...

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Detalles Bibliográficos
Autores principales: Liu, Sharon, Garrison, Scott R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446780/
https://www.ncbi.nlm.nih.gov/pubmed/36064448
http://dx.doi.org/10.1186/s13063-022-06689-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446780/
https://www.ncbi.nlm.nih.gov/pubmed/36064448
http://dx.doi.org/10.1186/s13063-022-06689-9

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