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Overestimation of benefit when clinical trials stop early: a simulation study
BACKGROUND: Stopping trials early because of a favourable interim analysis can exaggerate benefit. This study simulated trials typical of those stopping early for benefit in the real world and estimated the degree to which early stopping likely overestimates benefit. METHODS: From 1 million simulate...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446780/ https://www.ncbi.nlm.nih.gov/pubmed/36064448 http://dx.doi.org/10.1186/s13063-022-06689-9 |