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Intravoxel incoherent motion imaging combined with diffusion kurtosis imaging to assess the response to radiotherapy in a rabbit VX2 malignant bone tumor model
PURPOSE: To combine intravoxel incoherent motion (IVIM) imaging and diffusion kurtosis imaging (DKI) parameters for the evaluation of radiotherapy response in rabbit VX2 malignant bone tumor model. MATERIAL AND METHODS: Forty-seven rabbits with bone tumor were prospectively enrolled and divided into...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446876/ https://www.ncbi.nlm.nih.gov/pubmed/36064445 http://dx.doi.org/10.1186/s40644-022-00488-w |
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author | Guo, Jia Sun, Weikai Dong, Cheng Wu, Zengjie Li, Xiaoli Zhou, Ruizhi Xu, Wenjian |
author_facet | Guo, Jia Sun, Weikai Dong, Cheng Wu, Zengjie Li, Xiaoli Zhou, Ruizhi Xu, Wenjian |
author_sort | Guo, Jia |
collection | PubMed |
description | PURPOSE: To combine intravoxel incoherent motion (IVIM) imaging and diffusion kurtosis imaging (DKI) parameters for the evaluation of radiotherapy response in rabbit VX2 malignant bone tumor model. MATERIAL AND METHODS: Forty-seven rabbits with bone tumor were prospectively enrolled and divided into pre-treatment, considerable effect and slight effect group. Treatment response was evaluated using IVIM-DKI. IVIM-based parameters (tissue diffusion [Dt], pseudo-diffusion [Dp], perfusion fraction [fp]), and DKI-based parameters (mean diffusion coefficient [MD] and mean kurtosis [MK]) were calculated for each animal. Corresponding changes in MRI parameters before and after radiotherapy in each group were studied with one-way ANOVA. Correlations of diffusion parameters of IVIM and DKI model were computed using Pearson’s correlation test. A diagnostic model combining different diffusion parameters was established using binary logistic regression, and its ROC curve was used to evaluate its diagnostic performance for determining considerable and slight effect to malignant bone tumor. RESULTS: After radiotherapy, Dt and MD increased, whereas fp and MK decreased (p < 0.05). The differences in Dt, fp, MD, and MK between considerable effect and slight effect groups were statistically significant (p < 0.05). A combination of Dt, fp, and MK had the best diagnostic performance for differentiating considerable effect from slight effect (AUC = 0.913, p < 0.001). CONCLUSIONS: A combination of IVIM- and DKI-based parameters allowed the non-invasive assessment of cellular, vascular, and microstructural changes in malignant bone tumors after radiotherapy, and holds great potential for monitoring the efficacy of tumor radiotherapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40644-022-00488-w. |
format | Online Article Text |
id | pubmed-9446876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94468762022-09-07 Intravoxel incoherent motion imaging combined with diffusion kurtosis imaging to assess the response to radiotherapy in a rabbit VX2 malignant bone tumor model Guo, Jia Sun, Weikai Dong, Cheng Wu, Zengjie Li, Xiaoli Zhou, Ruizhi Xu, Wenjian Cancer Imaging Research Article PURPOSE: To combine intravoxel incoherent motion (IVIM) imaging and diffusion kurtosis imaging (DKI) parameters for the evaluation of radiotherapy response in rabbit VX2 malignant bone tumor model. MATERIAL AND METHODS: Forty-seven rabbits with bone tumor were prospectively enrolled and divided into pre-treatment, considerable effect and slight effect group. Treatment response was evaluated using IVIM-DKI. IVIM-based parameters (tissue diffusion [Dt], pseudo-diffusion [Dp], perfusion fraction [fp]), and DKI-based parameters (mean diffusion coefficient [MD] and mean kurtosis [MK]) were calculated for each animal. Corresponding changes in MRI parameters before and after radiotherapy in each group were studied with one-way ANOVA. Correlations of diffusion parameters of IVIM and DKI model were computed using Pearson’s correlation test. A diagnostic model combining different diffusion parameters was established using binary logistic regression, and its ROC curve was used to evaluate its diagnostic performance for determining considerable and slight effect to malignant bone tumor. RESULTS: After radiotherapy, Dt and MD increased, whereas fp and MK decreased (p < 0.05). The differences in Dt, fp, MD, and MK between considerable effect and slight effect groups were statistically significant (p < 0.05). A combination of Dt, fp, and MK had the best diagnostic performance for differentiating considerable effect from slight effect (AUC = 0.913, p < 0.001). CONCLUSIONS: A combination of IVIM- and DKI-based parameters allowed the non-invasive assessment of cellular, vascular, and microstructural changes in malignant bone tumors after radiotherapy, and holds great potential for monitoring the efficacy of tumor radiotherapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40644-022-00488-w. BioMed Central 2022-09-05 /pmc/articles/PMC9446876/ /pubmed/36064445 http://dx.doi.org/10.1186/s40644-022-00488-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Guo, Jia Sun, Weikai Dong, Cheng Wu, Zengjie Li, Xiaoli Zhou, Ruizhi Xu, Wenjian Intravoxel incoherent motion imaging combined with diffusion kurtosis imaging to assess the response to radiotherapy in a rabbit VX2 malignant bone tumor model |
title | Intravoxel incoherent motion imaging combined with diffusion kurtosis imaging to assess the response to radiotherapy in a rabbit VX2 malignant bone tumor model |
title_full | Intravoxel incoherent motion imaging combined with diffusion kurtosis imaging to assess the response to radiotherapy in a rabbit VX2 malignant bone tumor model |
title_fullStr | Intravoxel incoherent motion imaging combined with diffusion kurtosis imaging to assess the response to radiotherapy in a rabbit VX2 malignant bone tumor model |
title_full_unstemmed | Intravoxel incoherent motion imaging combined with diffusion kurtosis imaging to assess the response to radiotherapy in a rabbit VX2 malignant bone tumor model |
title_short | Intravoxel incoherent motion imaging combined with diffusion kurtosis imaging to assess the response to radiotherapy in a rabbit VX2 malignant bone tumor model |
title_sort | intravoxel incoherent motion imaging combined with diffusion kurtosis imaging to assess the response to radiotherapy in a rabbit vx2 malignant bone tumor model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446876/ https://www.ncbi.nlm.nih.gov/pubmed/36064445 http://dx.doi.org/10.1186/s40644-022-00488-w |
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