Anti-Extra Domain B Splice Variant of Fibronectin Antibody–Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade

Extra domain B splice variant of fibronectin (EDB+FN) is an extracellular matrix protein (ECM) deposited by tumor-associated fibroblasts, and is associated with tumor growth, angiogenesis, and invasion. We hypothesized that EDB+FN is a safe and abundant target for therapeutic intervention with an an...

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Detalles Bibliográficos
Autores principales: Hooper, Andrea T., Marquette, Kimberly, Chang, Chao-Pei Betty, Golas, Jonathon, Jain, Sadhana, Lam, My-Hanh, Guffroy, Magali, Leal, Mauricio, Falahatpisheh, Hadi, Mathur, Divya, Chen, Ting, Kelleher, Kerry, Khandke, Kiran, Muszynska, Elwira, Loganzo, Frank, Rosfjord, Edward, Lucas, Judy, Kan, Zhengyan, Subramanyam, Chakrapani, O'Donnell, Christopher, Neri, Dario, Gerber, Hans-Peter, May, Chad, Sapra, Puja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Large Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446899/
https://www.ncbi.nlm.nih.gov/pubmed/35793468
http://dx.doi.org/10.1158/1535-7163.MCT-22-0099

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