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Computer simulations of Template-Directed RNA Synthesis driven by temperature cycling in diverse sequence mixtures
We present simulations of non-enzymatic template-directed RNA synthesis that incorporate primer extension, ligation, melting, and reannealing. Strand growth occurs over multiple heating/cooling cycles, producing strands of several hundred nucleotides in length, starting with random oligomers of 4 to...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9447872/ https://www.ncbi.nlm.nih.gov/pubmed/36001640 http://dx.doi.org/10.1371/journal.pcbi.1010458 |