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Computer simulations of Template-Directed RNA Synthesis driven by temperature cycling in diverse sequence mixtures

We present simulations of non-enzymatic template-directed RNA synthesis that incorporate primer extension, ligation, melting, and reannealing. Strand growth occurs over multiple heating/cooling cycles, producing strands of several hundred nucleotides in length, starting with random oligomers of 4 to...

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Detalles Bibliográficos
Autores principales:	Chamanian, Pouyan, Higgs, Paul G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9447872/ https://www.ncbi.nlm.nih.gov/pubmed/36001640 http://dx.doi.org/10.1371/journal.pcbi.1010458

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