Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional genetic screens in palbociclib-resistant cells. Using th...

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Detalles Bibliográficos
Autores principales: Pogacar, Ziva, Johnson, Jackie L., Krenning, Lenno, De Conti, Giulia, Jochems, Fleur, Lieftink, Cor, Velds, Arno, Wardak, Leyma, Groot, Kelvin, Schepers, Arnout, Wang, Liqin, Song, Ji-Ying, van de Ven, Marieke, van Tellingen, Olaf, Medema, Rene H., Beijersbergen, Roderick L., Bernards, Rene, Leite de Oliveira, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9447877/
https://www.ncbi.nlm.nih.gov/pubmed/36067171
http://dx.doi.org/10.1371/journal.pone.0273182

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