Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC

Misidentification, cross-contamination and genetic drift of continuous animal cell lines are persistent problems in biomedical research, leading to erroneous results and inconsistent or invalidated studies. The establishment of immortalized hepatic stellate cell line Col-GFP HSC was reported in PLoS...

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Detalles Bibliográficos
Autores principales: Meurer, Steffen K., Brenner, David A., Weiskirchen, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9447916/
https://www.ncbi.nlm.nih.gov/pubmed/36067186
http://dx.doi.org/10.1371/journal.pone.0274219
Descripción
Sumario:Misidentification, cross-contamination and genetic drift of continuous animal cell lines are persistent problems in biomedical research, leading to erroneous results and inconsistent or invalidated studies. The establishment of immortalized hepatic stellate cell line Col-GFP HSC was reported in PLoS One in the year 2013. In the present study a multi loci short tandem repeat signature for this cell line was established that allows for unique cell line authentication.

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