The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population

BACKGROUND: Kawasaki disease (KD) was one of the most common primary vasculitis. IVIG resistance was associated with an increased risk of coronary artery aneurysm. Accumulating evidences demonstrated that inflammatory gene polymorphisms might play important roles in IVIG resistance, and zinc finger...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Zhaojin, Zheng, Zepeng, Xu, Yufen, Wang, Chenlu, Lin, Yueling, Lin, Kun, Fu, LanYan, Zhou, Huazhong, Pi, Lei, Che, Di, Gu, Xiaoqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448350/
https://www.ncbi.nlm.nih.gov/pubmed/36081762
http://dx.doi.org/10.2147/JIR.S378080
_version_ 1784784040917729280
author Lu, Zhaojin
Zheng, Zepeng
Xu, Yufen
Wang, Chenlu
Lin, Yueling
Lin, Kun
Fu, LanYan
Zhou, Huazhong
Pi, Lei
Che, Di
Gu, Xiaoqiong
author_facet Lu, Zhaojin
Zheng, Zepeng
Xu, Yufen
Wang, Chenlu
Lin, Yueling
Lin, Kun
Fu, LanYan
Zhou, Huazhong
Pi, Lei
Che, Di
Gu, Xiaoqiong
author_sort Lu, Zhaojin
collection PubMed
description BACKGROUND: Kawasaki disease (KD) was one of the most common primary vasculitis. IVIG resistance was associated with an increased risk of coronary artery aneurysm. Accumulating evidences demonstrated that inflammatory gene polymorphisms might play important roles in IVIG resistance, and zinc finger proteins were closely related to immune inflammation regulation, but the effect of ZNF112/rs8113807 and ZNF180/rs2571051 on IVIG resistance in KD patients has not been reported. METHODS: A total of 996 KD patients were recruited, and the assay of TaqMan-real-time polymerase chain reaction was used for ZNF112/rs8113807 and ZNF180/rs2571051 genotyping. Odds ratio (OR) and 95% confidence interval (CI) were calculated for estimating the relationship between the polymorphisms of the both SNPs (ZNF112/rs8113807 and ZNF180/rs2571051) and the risk of IVIG resistance. RESULTS: Both of the ZNF112/rs8113807 CC/TC genotype and the ZNF180/rs2571051 TT/CT genotype increased the risk of IVIG resistance in KD (rs8113807: CC vs TT: adjusted OR = 1.83, 95% CI = 1.06–3.16, p = 0.0293; CC/TC vs TT adjusted: OR = 1.49, 95% CI = 1.10–2.02, p = 0.0094. rs2571051: TT vs CC adjusted: OR = 2.64, 95% CI = 1.62–4.29, p < 0.0001; TT/CT vs CC adjusted: OR = 2.14, 95% CI = 1.37–3.37, p = 0.0009; TT vs CC/CT adjusted: OR = 1.66, 95% CI = 1.22–2.27, p = 0.0014). Furthermore, the combinative analysis of risk genotypes in ZNF112/rs8113807 and ZNF180/rs2571051 showed that patients with two unfavorable genotypes were more likely to increase risk of IVIG resistance than those who carried with zero or one unfavorable genotypes (adjusted: OR = 1.68, 95% CI = 1.24–2.27, p = 0.0008). CONCLUSION: Our findings enriched the genetic background of IVIG resistance risk in the KD development and suggested that the ZNF112/rs8113807 C-carrier and the ZNF180/rs2571051 T-carrier were associated with increased risk of IVIG resistance in KD patients in Chinese southern population.
format Online
Article
Text
id pubmed-9448350
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-94483502022-09-07 The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population Lu, Zhaojin Zheng, Zepeng Xu, Yufen Wang, Chenlu Lin, Yueling Lin, Kun Fu, LanYan Zhou, Huazhong Pi, Lei Che, Di Gu, Xiaoqiong J Inflamm Res Original Research BACKGROUND: Kawasaki disease (KD) was one of the most common primary vasculitis. IVIG resistance was associated with an increased risk of coronary artery aneurysm. Accumulating evidences demonstrated that inflammatory gene polymorphisms might play important roles in IVIG resistance, and zinc finger proteins were closely related to immune inflammation regulation, but the effect of ZNF112/rs8113807 and ZNF180/rs2571051 on IVIG resistance in KD patients has not been reported. METHODS: A total of 996 KD patients were recruited, and the assay of TaqMan-real-time polymerase chain reaction was used for ZNF112/rs8113807 and ZNF180/rs2571051 genotyping. Odds ratio (OR) and 95% confidence interval (CI) were calculated for estimating the relationship between the polymorphisms of the both SNPs (ZNF112/rs8113807 and ZNF180/rs2571051) and the risk of IVIG resistance. RESULTS: Both of the ZNF112/rs8113807 CC/TC genotype and the ZNF180/rs2571051 TT/CT genotype increased the risk of IVIG resistance in KD (rs8113807: CC vs TT: adjusted OR = 1.83, 95% CI = 1.06–3.16, p = 0.0293; CC/TC vs TT adjusted: OR = 1.49, 95% CI = 1.10–2.02, p = 0.0094. rs2571051: TT vs CC adjusted: OR = 2.64, 95% CI = 1.62–4.29, p < 0.0001; TT/CT vs CC adjusted: OR = 2.14, 95% CI = 1.37–3.37, p = 0.0009; TT vs CC/CT adjusted: OR = 1.66, 95% CI = 1.22–2.27, p = 0.0014). Furthermore, the combinative analysis of risk genotypes in ZNF112/rs8113807 and ZNF180/rs2571051 showed that patients with two unfavorable genotypes were more likely to increase risk of IVIG resistance than those who carried with zero or one unfavorable genotypes (adjusted: OR = 1.68, 95% CI = 1.24–2.27, p = 0.0008). CONCLUSION: Our findings enriched the genetic background of IVIG resistance risk in the KD development and suggested that the ZNF112/rs8113807 C-carrier and the ZNF180/rs2571051 T-carrier were associated with increased risk of IVIG resistance in KD patients in Chinese southern population. Dove 2022-09-02 /pmc/articles/PMC9448350/ /pubmed/36081762 http://dx.doi.org/10.2147/JIR.S378080 Text en © 2022 Lu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Lu, Zhaojin
Zheng, Zepeng
Xu, Yufen
Wang, Chenlu
Lin, Yueling
Lin, Kun
Fu, LanYan
Zhou, Huazhong
Pi, Lei
Che, Di
Gu, Xiaoqiong
The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population
title The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population
title_full The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population
title_fullStr The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population
title_full_unstemmed The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population
title_short The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population
title_sort associated of the risk of ivig resistance in kawasaki disease with znf112 gene and znf180 gene in a southern chinese population
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448350/
https://www.ncbi.nlm.nih.gov/pubmed/36081762
http://dx.doi.org/10.2147/JIR.S378080
work_keys_str_mv AT luzhaojin theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT zhengzepeng theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT xuyufen theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT wangchenlu theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT linyueling theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT linkun theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT fulanyan theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT zhouhuazhong theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT pilei theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT chedi theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT guxiaoqiong theassociatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT luzhaojin associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT zhengzepeng associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT xuyufen associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT wangchenlu associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT linyueling associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT linkun associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT fulanyan associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT zhouhuazhong associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT pilei associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT chedi associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation
AT guxiaoqiong associatedoftheriskofivigresistanceinkawasakidiseasewithznf112geneandznf180geneinasouthernchinesepopulation

Ejemplares similares