Rational design, synthesis, and pharmacological characterisation of dicarbonyl curcuminoid analogues with improved stability against lung cancer via ROS and ER stress mediated cell apoptosis and pyroptosis

Curcumin is a natural medicine with a wide range of anti-tumour activities. However, due to β-diketone moiety, curcumin exhibits poor stability and pharmacokinetics which significantly limits its clinical applications. In this article, two types of dicarbonyl curcumin analogues with improved stabili...

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Detalles Bibliográficos
Autores principales: Wei, Tao, Zheng, Zhiwei, Wei, Xiaoyan, Liu, Yugang, Li, Wentao, Fang, Bingqing, Yun, Di, Dong, Zhaojun, Yi, Baozhu, Li, Wulan, Wu, Xiaoping, Chen, Dezhi, Chen, Liping, Wu, Jianzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448362/
https://www.ncbi.nlm.nih.gov/pubmed/36039017
http://dx.doi.org/10.1080/14756366.2022.2116015

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