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Geriatric risk and protective factors for serious COVID-19 outcomes among older adults in Shanghai Omicron wave
Shanghai has been experiencing the Omicron wave since March 2022. Though several studies have evaluated the risk factors of severe infections, the analyses of BA.2 infection risk and protective factors among geriatric people were much limited. This multicentre cohort study described clinical charact...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448390/ https://www.ncbi.nlm.nih.gov/pubmed/35924388 http://dx.doi.org/10.1080/22221751.2022.2109517 |
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author | Lu, Guanzhu Zhang, Yi Zhang, Haocheng Ai, Jingwen He, Liu Yuan, Xiaoling Bao, Suxia Chen, Xiaohua Wang, Hongyu Cai, Jianpeng Wang, Sen Zhang, Wenhong Xu, Jie |
author_facet | Lu, Guanzhu Zhang, Yi Zhang, Haocheng Ai, Jingwen He, Liu Yuan, Xiaoling Bao, Suxia Chen, Xiaohua Wang, Hongyu Cai, Jianpeng Wang, Sen Zhang, Wenhong Xu, Jie |
author_sort | Lu, Guanzhu |
collection | PubMed |
description | Shanghai has been experiencing the Omicron wave since March 2022. Though several studies have evaluated the risk factors of severe infections, the analyses of BA.2 infection risk and protective factors among geriatric people were much limited. This multicentre cohort study described clinical characteristics, and assessed risk and protective factors for geriatric Omicron severe infections. A total of 1377 patients older than 60 were enrolled, with 75.96% having comorbidities. The median viral shedding time and hospitalization time were nine and eight days, respectively. Severe and critical were associated with longer virus clearance time (aOR [95%CI]:0.706 (0.533–0.935), P = .015), while fully vaccinated/booster and paxlovid use shortened viral shedding time (1.229 [1.076–1.402], P = .002; 1.140 [0.019–1.274], P = .022, respectively). Older age (>80), cerebrovascular disease, and chronic kidney disease were risk factors of severe/critical. Fully vaccination was a significant protective factor against severe infections (0.237 [0.071–0.793], P = .019). We found patients with more than two comorbidities were more likely to get serious outcomes. These findings demonstrated that in the elderly older than 60 years old, older age (aged over 80), cerebrovascular disease, and chronic kidney disease were risk factors for severe infection. Patients with more than two comorbidities were more likely to get serious outcomes. Fully vaccinated/booster patients were less likely to be severe and vaccinations could shorten viral shedding time. The limitation of lacking an overall spectrum of COVID-19 infections among elders could be compensated in other larger-scale studies in the future. |
format | Online Article Text |
id | pubmed-9448390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-94483902022-09-07 Geriatric risk and protective factors for serious COVID-19 outcomes among older adults in Shanghai Omicron wave Lu, Guanzhu Zhang, Yi Zhang, Haocheng Ai, Jingwen He, Liu Yuan, Xiaoling Bao, Suxia Chen, Xiaohua Wang, Hongyu Cai, Jianpeng Wang, Sen Zhang, Wenhong Xu, Jie Emerg Microbes Infect Coronaviruses Shanghai has been experiencing the Omicron wave since March 2022. Though several studies have evaluated the risk factors of severe infections, the analyses of BA.2 infection risk and protective factors among geriatric people were much limited. This multicentre cohort study described clinical characteristics, and assessed risk and protective factors for geriatric Omicron severe infections. A total of 1377 patients older than 60 were enrolled, with 75.96% having comorbidities. The median viral shedding time and hospitalization time were nine and eight days, respectively. Severe and critical were associated with longer virus clearance time (aOR [95%CI]:0.706 (0.533–0.935), P = .015), while fully vaccinated/booster and paxlovid use shortened viral shedding time (1.229 [1.076–1.402], P = .002; 1.140 [0.019–1.274], P = .022, respectively). Older age (>80), cerebrovascular disease, and chronic kidney disease were risk factors of severe/critical. Fully vaccination was a significant protective factor against severe infections (0.237 [0.071–0.793], P = .019). We found patients with more than two comorbidities were more likely to get serious outcomes. These findings demonstrated that in the elderly older than 60 years old, older age (aged over 80), cerebrovascular disease, and chronic kidney disease were risk factors for severe infection. Patients with more than two comorbidities were more likely to get serious outcomes. Fully vaccinated/booster patients were less likely to be severe and vaccinations could shorten viral shedding time. The limitation of lacking an overall spectrum of COVID-19 infections among elders could be compensated in other larger-scale studies in the future. Taylor & Francis 2022-08-31 /pmc/articles/PMC9448390/ /pubmed/35924388 http://dx.doi.org/10.1080/22221751.2022.2109517 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Coronaviruses Lu, Guanzhu Zhang, Yi Zhang, Haocheng Ai, Jingwen He, Liu Yuan, Xiaoling Bao, Suxia Chen, Xiaohua Wang, Hongyu Cai, Jianpeng Wang, Sen Zhang, Wenhong Xu, Jie Geriatric risk and protective factors for serious COVID-19 outcomes among older adults in Shanghai Omicron wave |
title | Geriatric risk and protective factors for serious COVID-19 outcomes among older adults in Shanghai Omicron wave |
title_full | Geriatric risk and protective factors for serious COVID-19 outcomes among older adults in Shanghai Omicron wave |
title_fullStr | Geriatric risk and protective factors for serious COVID-19 outcomes among older adults in Shanghai Omicron wave |
title_full_unstemmed | Geriatric risk and protective factors for serious COVID-19 outcomes among older adults in Shanghai Omicron wave |
title_short | Geriatric risk and protective factors for serious COVID-19 outcomes among older adults in Shanghai Omicron wave |
title_sort | geriatric risk and protective factors for serious covid-19 outcomes among older adults in shanghai omicron wave |
topic | Coronaviruses |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448390/ https://www.ncbi.nlm.nih.gov/pubmed/35924388 http://dx.doi.org/10.1080/22221751.2022.2109517 |
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