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NAT10 regulates neutrophil pyroptosis in sepsis via acetylating ULK1 RNA and activating STING pathway

Emerging evidence suggests that pyroptosis is involved in sepsis. However, the role of neutrophil pyroptosis in sepsis and the mechanisms remains elusive. We find that N-acetyltransferase 10 (NAT10), an acetyltransferase responsible for the N(4)-acetylation of Cytidine (ac(4)C) in mRNA, is significa...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Chen, Zhaoyuan, Zhou, Ji’an, Gu, Jiahui, Wu, Han, Jiang, Yi, Gao, Shenjia, Liao, Yun, Shen, Ruling, Miao, Changhong, Chen, Wankun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448771/
https://www.ncbi.nlm.nih.gov/pubmed/36068299
http://dx.doi.org/10.1038/s42003-022-03868-x