A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype

Cardiac fibrosis is associated with activation of cardiac fibroblasts (CFs), a pathological, phenotypic transition that is widely believed to be irreversible in the late stages of disease development. Sensing of a stiffened mechanical environment through regulation of integrin-based adhesion plaques...

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Detalles Bibliográficos
Autores principales: Niu, Lele, Cheng, Bo, Huang, Guoyou, Nan, Kai, Han, Shuang, Ren, Hui, Liu, Na, Li, Yan, Genin, Guy M., Xu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448780/
https://www.ncbi.nlm.nih.gov/pubmed/36068215
http://dx.doi.org/10.1038/s41421-022-00427-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448780/
https://www.ncbi.nlm.nih.gov/pubmed/36068215
http://dx.doi.org/10.1038/s41421-022-00427-w

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