Cargando…

Highly efficient passive Tesla valves for microfluidic applications

A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates, characteristic, e.g., for almost all microfluidic systems, where passive valves have intrinsic advantages over active ones. We report on optimized structures that show a diodicity of up to...

Descripción completa

Detalles Bibliográficos
Autores principales: Bohm, Sebastian, Phi, Hai Binh, Moriyama, Ayaka, Runge, Erich, Strehle, Steffen, König, Jörg, Cierpka, Christian, Dittrich, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448783/
https://www.ncbi.nlm.nih.gov/pubmed/36089943
http://dx.doi.org/10.1038/s41378-022-00437-4
_version_ 1784784142954659840
author Bohm, Sebastian
Phi, Hai Binh
Moriyama, Ayaka
Runge, Erich
Strehle, Steffen
König, Jörg
Cierpka, Christian
Dittrich, Lars
author_facet Bohm, Sebastian
Phi, Hai Binh
Moriyama, Ayaka
Runge, Erich
Strehle, Steffen
König, Jörg
Cierpka, Christian
Dittrich, Lars
author_sort Bohm, Sebastian
collection PubMed
description A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates, characteristic, e.g., for almost all microfluidic systems, where passive valves have intrinsic advantages over active ones. We report on optimized structures that show a diodicity of up to 1.8 already at flow rates of 20 μl s(−)(1) corresponding to a Reynolds number of 36. Centerpiece of the design is a topological optimization based on the finite element method. It is set-up to yield easy-to-fabricate valve structures with a small footprint that can be directly used in microfluidic systems. Our numerical two-dimensional optimization takes into account the finite height of the channel approximately by means of a so-called shallow-channel approximation. Based on the three-dimensionally extruded optimized designs, various test structures were fabricated using standard, widely available microsystem manufacturing techniques. The manufacturing process is described in detail since it can be used for the production of similar cost-effective microfluidic systems. For the experimentally fabricated chips, the efficiency of the different valve designs, i.e., the diodicity defined as the ratio of the measured pressure drops in backward and forward flow directions, respectively, is measured and compared to theoretical predictions obtained from full 3D calculations of the Tesla valves. Good agreement is found. In addition to the direct measurement of the diodicities, the flow profiles in the fabricated test structures are determined using a two-dimensional microscopic particle image velocimetry (μPIV) method. Again, a reasonable good agreement of the measured flow profiles with simulated predictions is observed.
format Online
Article
Text
id pubmed-9448783
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-94487832022-09-08 Highly efficient passive Tesla valves for microfluidic applications Bohm, Sebastian Phi, Hai Binh Moriyama, Ayaka Runge, Erich Strehle, Steffen König, Jörg Cierpka, Christian Dittrich, Lars Microsyst Nanoeng Article A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates, characteristic, e.g., for almost all microfluidic systems, where passive valves have intrinsic advantages over active ones. We report on optimized structures that show a diodicity of up to 1.8 already at flow rates of 20 μl s(−)(1) corresponding to a Reynolds number of 36. Centerpiece of the design is a topological optimization based on the finite element method. It is set-up to yield easy-to-fabricate valve structures with a small footprint that can be directly used in microfluidic systems. Our numerical two-dimensional optimization takes into account the finite height of the channel approximately by means of a so-called shallow-channel approximation. Based on the three-dimensionally extruded optimized designs, various test structures were fabricated using standard, widely available microsystem manufacturing techniques. The manufacturing process is described in detail since it can be used for the production of similar cost-effective microfluidic systems. For the experimentally fabricated chips, the efficiency of the different valve designs, i.e., the diodicity defined as the ratio of the measured pressure drops in backward and forward flow directions, respectively, is measured and compared to theoretical predictions obtained from full 3D calculations of the Tesla valves. Good agreement is found. In addition to the direct measurement of the diodicities, the flow profiles in the fabricated test structures are determined using a two-dimensional microscopic particle image velocimetry (μPIV) method. Again, a reasonable good agreement of the measured flow profiles with simulated predictions is observed. Nature Publishing Group UK 2022-09-07 /pmc/articles/PMC9448783/ /pubmed/36089943 http://dx.doi.org/10.1038/s41378-022-00437-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bohm, Sebastian
Phi, Hai Binh
Moriyama, Ayaka
Runge, Erich
Strehle, Steffen
König, Jörg
Cierpka, Christian
Dittrich, Lars
Highly efficient passive Tesla valves for microfluidic applications
title Highly efficient passive Tesla valves for microfluidic applications
title_full Highly efficient passive Tesla valves for microfluidic applications
title_fullStr Highly efficient passive Tesla valves for microfluidic applications
title_full_unstemmed Highly efficient passive Tesla valves for microfluidic applications
title_short Highly efficient passive Tesla valves for microfluidic applications
title_sort highly efficient passive tesla valves for microfluidic applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448783/
https://www.ncbi.nlm.nih.gov/pubmed/36089943
http://dx.doi.org/10.1038/s41378-022-00437-4
work_keys_str_mv AT bohmsebastian highlyefficientpassiveteslavalvesformicrofluidicapplications
AT phihaibinh highlyefficientpassiveteslavalvesformicrofluidicapplications
AT moriyamaayaka highlyefficientpassiveteslavalvesformicrofluidicapplications
AT rungeerich highlyefficientpassiveteslavalvesformicrofluidicapplications
AT strehlesteffen highlyefficientpassiveteslavalvesformicrofluidicapplications
AT konigjorg highlyefficientpassiveteslavalvesformicrofluidicapplications
AT cierpkachristian highlyefficientpassiveteslavalvesformicrofluidicapplications
AT dittrichlars highlyefficientpassiveteslavalvesformicrofluidicapplications