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Highly efficient passive Tesla valves for microfluidic applications
A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates, characteristic, e.g., for almost all microfluidic systems, where passive valves have intrinsic advantages over active ones. We report on optimized structures that show a diodicity of up to...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448783/ https://www.ncbi.nlm.nih.gov/pubmed/36089943 http://dx.doi.org/10.1038/s41378-022-00437-4 |
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author | Bohm, Sebastian Phi, Hai Binh Moriyama, Ayaka Runge, Erich Strehle, Steffen König, Jörg Cierpka, Christian Dittrich, Lars |
author_facet | Bohm, Sebastian Phi, Hai Binh Moriyama, Ayaka Runge, Erich Strehle, Steffen König, Jörg Cierpka, Christian Dittrich, Lars |
author_sort | Bohm, Sebastian |
collection | PubMed |
description | A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates, characteristic, e.g., for almost all microfluidic systems, where passive valves have intrinsic advantages over active ones. We report on optimized structures that show a diodicity of up to 1.8 already at flow rates of 20 μl s(−)(1) corresponding to a Reynolds number of 36. Centerpiece of the design is a topological optimization based on the finite element method. It is set-up to yield easy-to-fabricate valve structures with a small footprint that can be directly used in microfluidic systems. Our numerical two-dimensional optimization takes into account the finite height of the channel approximately by means of a so-called shallow-channel approximation. Based on the three-dimensionally extruded optimized designs, various test structures were fabricated using standard, widely available microsystem manufacturing techniques. The manufacturing process is described in detail since it can be used for the production of similar cost-effective microfluidic systems. For the experimentally fabricated chips, the efficiency of the different valve designs, i.e., the diodicity defined as the ratio of the measured pressure drops in backward and forward flow directions, respectively, is measured and compared to theoretical predictions obtained from full 3D calculations of the Tesla valves. Good agreement is found. In addition to the direct measurement of the diodicities, the flow profiles in the fabricated test structures are determined using a two-dimensional microscopic particle image velocimetry (μPIV) method. Again, a reasonable good agreement of the measured flow profiles with simulated predictions is observed. |
format | Online Article Text |
id | pubmed-9448783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-94487832022-09-08 Highly efficient passive Tesla valves for microfluidic applications Bohm, Sebastian Phi, Hai Binh Moriyama, Ayaka Runge, Erich Strehle, Steffen König, Jörg Cierpka, Christian Dittrich, Lars Microsyst Nanoeng Article A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates, characteristic, e.g., for almost all microfluidic systems, where passive valves have intrinsic advantages over active ones. We report on optimized structures that show a diodicity of up to 1.8 already at flow rates of 20 μl s(−)(1) corresponding to a Reynolds number of 36. Centerpiece of the design is a topological optimization based on the finite element method. It is set-up to yield easy-to-fabricate valve structures with a small footprint that can be directly used in microfluidic systems. Our numerical two-dimensional optimization takes into account the finite height of the channel approximately by means of a so-called shallow-channel approximation. Based on the three-dimensionally extruded optimized designs, various test structures were fabricated using standard, widely available microsystem manufacturing techniques. The manufacturing process is described in detail since it can be used for the production of similar cost-effective microfluidic systems. For the experimentally fabricated chips, the efficiency of the different valve designs, i.e., the diodicity defined as the ratio of the measured pressure drops in backward and forward flow directions, respectively, is measured and compared to theoretical predictions obtained from full 3D calculations of the Tesla valves. Good agreement is found. In addition to the direct measurement of the diodicities, the flow profiles in the fabricated test structures are determined using a two-dimensional microscopic particle image velocimetry (μPIV) method. Again, a reasonable good agreement of the measured flow profiles with simulated predictions is observed. Nature Publishing Group UK 2022-09-07 /pmc/articles/PMC9448783/ /pubmed/36089943 http://dx.doi.org/10.1038/s41378-022-00437-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Bohm, Sebastian Phi, Hai Binh Moriyama, Ayaka Runge, Erich Strehle, Steffen König, Jörg Cierpka, Christian Dittrich, Lars Highly efficient passive Tesla valves for microfluidic applications |
title | Highly efficient passive Tesla valves for microfluidic applications |
title_full | Highly efficient passive Tesla valves for microfluidic applications |
title_fullStr | Highly efficient passive Tesla valves for microfluidic applications |
title_full_unstemmed | Highly efficient passive Tesla valves for microfluidic applications |
title_short | Highly efficient passive Tesla valves for microfluidic applications |
title_sort | highly efficient passive tesla valves for microfluidic applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448783/ https://www.ncbi.nlm.nih.gov/pubmed/36089943 http://dx.doi.org/10.1038/s41378-022-00437-4 |
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