STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer

Poly (ADP-ribose) polymerase (PARP) inhibitors exert their efficacy via synthetic lethal effects and by inducing cGAS/STING-mediated immune responses. We demonstrate that compared to monotherapies, combined PARP inhibition and STING agonism results in increased STING pathway activation, greater cyto...

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Detalles Bibliográficos
Autores principales: Pantelidou, Constantia, Jadhav, Heta, Kothari, Aditi, Liu, Renyan, Wulf, Gerburg M., Guerriero, Jennifer L., Shapiro, Geoffrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448789/
https://www.ncbi.nlm.nih.gov/pubmed/36068244
http://dx.doi.org/10.1038/s41523-022-00471-5

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