Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8(+) T cells, is regulated by several intrinsic signaling pathways. Here, we found that tobacco smoke, a major public health concern that kills 8 million...

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Detalles Bibliográficos
Autores principales: Liang, Fan, Wang, Gui-Zhen, Wang, Yan, Yang, Ya-Ning, Wen, Zhe-Sheng, Chen, Dong-Ni, Fang, Wen-Feng, Zhang, Bin, Yang, Lu, Zhang, Chen, Han, Si-Chong, Yang, Fu-Ying, Wang, Di, Liang, Li-Jun, Wang, Zheng, Zhao, Yong, Wang, Chang-Li, Zhang, Li, Zhou, Guang-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448807/
https://www.ncbi.nlm.nih.gov/pubmed/36068203
http://dx.doi.org/10.1038/s41392-022-01127-3

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