A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase

Uterine leiomyomas, or fibroids, are the most common tumors in women of reproductive age. Uterine leiomyomas can be classified into at least three main molecular subtypes according to mutations affecting MED12, HMGA2, or FH. FH-deficient leiomyomas are characterized by activation of the NRF2 pathway...

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Detalles Bibliográficos
Autores principales: Mehine, Miika, Ahvenainen, Terhi, Khamaiseh, Sara, Härkönen, Jouni, Reinikka, Siiri, Heikkinen, Tuomas, Äyräväinen, Anna, Pakarinen, Päivi, Härkki, Päivi, Pasanen, Annukka, Levonen, Anna-Liisa, Bützow, Ralf, Vahteristo, Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448808/
https://www.ncbi.nlm.nih.gov/pubmed/36068196
http://dx.doi.org/10.1038/s41389-022-00425-3

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