Cargando…
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase
Uterine leiomyomas, or fibroids, are the most common tumors in women of reproductive age. Uterine leiomyomas can be classified into at least three main molecular subtypes according to mutations affecting MED12, HMGA2, or FH. FH-deficient leiomyomas are characterized by activation of the NRF2 pathway...
Autores principales: | Mehine, Miika, Ahvenainen, Terhi, Khamaiseh, Sara, Härkönen, Jouni, Reinikka, Siiri, Heikkinen, Tuomas, Äyräväinen, Anna, Pakarinen, Päivi, Härkki, Päivi, Pasanen, Annukka, Levonen, Anna-Liisa, Bützow, Ralf, Vahteristo, Pia |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448808/ https://www.ncbi.nlm.nih.gov/pubmed/36068196 http://dx.doi.org/10.1038/s41389-022-00425-3 |
Ejemplares similares
-
3′RNA and whole‐genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1
por: Jokinen, Vilja, et al.
Publicado: (2022) -
3′RNA Sequencing Accurately Classifies Formalin-Fixed Paraffin-Embedded Uterine Leiomyomas
por: Mehine, Miika, et al.
Publicado: (2020) -
MED12 mutations and fumarate hydratase inactivation in uterine adenomyomas
por: Heikkinen, Tuomas, et al.
Publicado: (2018) -
Differential impact of clinicopathological risk factors within the 2 largest ProMisE molecular subgroups of endometrial carcinoma
por: Pasanen, Annukka, et al.
Publicado: (2021) -
Global metabolomic profiling of uterine leiomyomas
por: Heinonen, Hanna-Riikka, et al.
Publicado: (2017)