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The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth

The presence of metastatic lymph nodes is a relevant prognostic factor in oral cancer. OBJECTIVE: This paper aims to assess metastatic lymph node density (pN+) in patients with tongue and floor-of-mouth squamous cell carcinoma (SCC) and the association of this parameter with disease-free survival (D...

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Autores principales: Amar, Ali, Rapoport, Abrão, Curioni, Otávio Alberto, Dedivitis, Rogério Aparecido, Cernea, Cláudio Roberto, Brandão, Lenine Garcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448944/
https://www.ncbi.nlm.nih.gov/pubmed/22714852
http://dx.doi.org/10.1590/S1808-86942012000300015
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author Amar, Ali
Rapoport, Abrão
Curioni, Otávio Alberto
Dedivitis, Rogério Aparecido
Cernea, Cláudio Roberto
Brandão, Lenine Garcia
author_facet Amar, Ali
Rapoport, Abrão
Curioni, Otávio Alberto
Dedivitis, Rogério Aparecido
Cernea, Cláudio Roberto
Brandão, Lenine Garcia
author_sort Amar, Ali
collection PubMed
description The presence of metastatic lymph nodes is a relevant prognostic factor in oral cancer. OBJECTIVE: This paper aims to assess metastatic lymph node density (pN+) in patients with tongue and floor-of-mouth squamous cell carcinoma (SCC) and the association of this parameter with disease-free survival (DFS). MATERIALS AND METHODS: A group of 182 patients seen between 1985 and 2007 was included, 169 of which were males. Five were on stage I, 35 on stage II, 56 on stage III, and 85 on stage IV. Median values were considered in lymph node density assessment, and the Kaplan-Meier curve was used to evaluate DFS; survival differences within the group were elicited through the log-rank test. RESULTS: An average 3.2 metastatic lymph nodes were excised from the patients in the group. Density ranged from 0.009 to 0.4, with a mean value of 0.09. Five-year DFS rates were of 44% and 28% for the groups with lymph node densities below and above the median respectively (p = 0.006). Two-year local/regional control was achieved for 71% and 49% for the patients below and above the median density respectively (p = 0.01). In terms of pN staging, local/ regional control was achieved in 70% and 54% of pN1 and pN2 patients respectively, albeit without statistical significance (0.20%). CONCLUSION: Lymph node density may be used as a prognostic indicator for tongue and floor-of-mouth SCC.
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spelling pubmed-94489442022-09-09 The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth Amar, Ali Rapoport, Abrão Curioni, Otávio Alberto Dedivitis, Rogério Aparecido Cernea, Cláudio Roberto Brandão, Lenine Garcia Braz J Otorhinolaryngol Original Article The presence of metastatic lymph nodes is a relevant prognostic factor in oral cancer. OBJECTIVE: This paper aims to assess metastatic lymph node density (pN+) in patients with tongue and floor-of-mouth squamous cell carcinoma (SCC) and the association of this parameter with disease-free survival (DFS). MATERIALS AND METHODS: A group of 182 patients seen between 1985 and 2007 was included, 169 of which were males. Five were on stage I, 35 on stage II, 56 on stage III, and 85 on stage IV. Median values were considered in lymph node density assessment, and the Kaplan-Meier curve was used to evaluate DFS; survival differences within the group were elicited through the log-rank test. RESULTS: An average 3.2 metastatic lymph nodes were excised from the patients in the group. Density ranged from 0.009 to 0.4, with a mean value of 0.09. Five-year DFS rates were of 44% and 28% for the groups with lymph node densities below and above the median respectively (p = 0.006). Two-year local/regional control was achieved for 71% and 49% for the patients below and above the median density respectively (p = 0.01). In terms of pN staging, local/ regional control was achieved in 70% and 54% of pN1 and pN2 patients respectively, albeit without statistical significance (0.20%). CONCLUSION: Lymph node density may be used as a prognostic indicator for tongue and floor-of-mouth SCC. Elsevier 2015-10-14 /pmc/articles/PMC9448944/ /pubmed/22714852 http://dx.doi.org/10.1590/S1808-86942012000300015 Text en © Neck Surgery of the Medical . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Amar, Ali
Rapoport, Abrão
Curioni, Otávio Alberto
Dedivitis, Rogério Aparecido
Cernea, Cláudio Roberto
Brandão, Lenine Garcia
The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth
title The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth
title_full The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth
title_fullStr The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth
title_full_unstemmed The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth
title_short The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth
title_sort density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448944/
https://www.ncbi.nlm.nih.gov/pubmed/22714852
http://dx.doi.org/10.1590/S1808-86942012000300015
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