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A Key Metabolic Regulator of Bone and Cartilage Health

Taurine, a cysteine-derived zwitterionic sulfonic acid, is a common ingredient in energy drinks and is naturally found in fish and other seafood. In humans, taurine is produced mainly in the liver, and it can also be obtained from food. In target tissues, such as the retina, heart, and skeletal musc...

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Autores principales: Pérez-Hernández, Elizabeth, Pastrana-Carballo, Jesús Javier, Gómez-Chávez, Fernando, Gupta, Ramesh C., Pérez-Hernández, Nury
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449101/
https://www.ncbi.nlm.nih.gov/pubmed/35938304
http://dx.doi.org/10.3803/EnM.2022.1443
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author Pérez-Hernández, Elizabeth
Pastrana-Carballo, Jesús Javier
Gómez-Chávez, Fernando
Gupta, Ramesh C.
Pérez-Hernández, Nury
author_facet Pérez-Hernández, Elizabeth
Pastrana-Carballo, Jesús Javier
Gómez-Chávez, Fernando
Gupta, Ramesh C.
Pérez-Hernández, Nury
author_sort Pérez-Hernández, Elizabeth
collection PubMed
description Taurine, a cysteine-derived zwitterionic sulfonic acid, is a common ingredient in energy drinks and is naturally found in fish and other seafood. In humans, taurine is produced mainly in the liver, and it can also be obtained from food. In target tissues, such as the retina, heart, and skeletal muscle, it functions as an essential antioxidant, osmolyte, and antiapoptotic agent. Taurine is also involved in energy metabolism and calcium homeostasis. Taurine plays a considerable role in bone growth and development, and high-profile reports have demonstrated the importance of its metabolism for bone health. However, these reports have not been collated for more than 10 years. Therefore, this review focuses on taurine–bone interactions and covers recently discovered aspects of taurine’s effects on osteoblastogenesis, osteoclastogenesis, bone structure, and bone pathologies (e.g., osteoporosis and fracture healing), with due attention to the taurine–cartilage relationship.
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spelling pubmed-94491012022-09-14 A Key Metabolic Regulator of Bone and Cartilage Health Pérez-Hernández, Elizabeth Pastrana-Carballo, Jesús Javier Gómez-Chávez, Fernando Gupta, Ramesh C. Pérez-Hernández, Nury Endocrinol Metab (Seoul) Review Article Taurine, a cysteine-derived zwitterionic sulfonic acid, is a common ingredient in energy drinks and is naturally found in fish and other seafood. In humans, taurine is produced mainly in the liver, and it can also be obtained from food. In target tissues, such as the retina, heart, and skeletal muscle, it functions as an essential antioxidant, osmolyte, and antiapoptotic agent. Taurine is also involved in energy metabolism and calcium homeostasis. Taurine plays a considerable role in bone growth and development, and high-profile reports have demonstrated the importance of its metabolism for bone health. However, these reports have not been collated for more than 10 years. Therefore, this review focuses on taurine–bone interactions and covers recently discovered aspects of taurine’s effects on osteoblastogenesis, osteoclastogenesis, bone structure, and bone pathologies (e.g., osteoporosis and fracture healing), with due attention to the taurine–cartilage relationship. Korean Endocrine Society 2022-08 2022-08-08 /pmc/articles/PMC9449101/ /pubmed/35938304 http://dx.doi.org/10.3803/EnM.2022.1443 Text en Copyright © 2022 Korean Endocrine Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pérez-Hernández, Elizabeth
Pastrana-Carballo, Jesús Javier
Gómez-Chávez, Fernando
Gupta, Ramesh C.
Pérez-Hernández, Nury
A Key Metabolic Regulator of Bone and Cartilage Health
title A Key Metabolic Regulator of Bone and Cartilage Health
title_full A Key Metabolic Regulator of Bone and Cartilage Health
title_fullStr A Key Metabolic Regulator of Bone and Cartilage Health
title_full_unstemmed A Key Metabolic Regulator of Bone and Cartilage Health
title_short A Key Metabolic Regulator of Bone and Cartilage Health
title_sort key metabolic regulator of bone and cartilage health
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449101/
https://www.ncbi.nlm.nih.gov/pubmed/35938304
http://dx.doi.org/10.3803/EnM.2022.1443
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