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A Key Metabolic Regulator of Bone and Cartilage Health
Taurine, a cysteine-derived zwitterionic sulfonic acid, is a common ingredient in energy drinks and is naturally found in fish and other seafood. In humans, taurine is produced mainly in the liver, and it can also be obtained from food. In target tissues, such as the retina, heart, and skeletal musc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Endocrine Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449101/ https://www.ncbi.nlm.nih.gov/pubmed/35938304 http://dx.doi.org/10.3803/EnM.2022.1443 |
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author | Pérez-Hernández, Elizabeth Pastrana-Carballo, Jesús Javier Gómez-Chávez, Fernando Gupta, Ramesh C. Pérez-Hernández, Nury |
author_facet | Pérez-Hernández, Elizabeth Pastrana-Carballo, Jesús Javier Gómez-Chávez, Fernando Gupta, Ramesh C. Pérez-Hernández, Nury |
author_sort | Pérez-Hernández, Elizabeth |
collection | PubMed |
description | Taurine, a cysteine-derived zwitterionic sulfonic acid, is a common ingredient in energy drinks and is naturally found in fish and other seafood. In humans, taurine is produced mainly in the liver, and it can also be obtained from food. In target tissues, such as the retina, heart, and skeletal muscle, it functions as an essential antioxidant, osmolyte, and antiapoptotic agent. Taurine is also involved in energy metabolism and calcium homeostasis. Taurine plays a considerable role in bone growth and development, and high-profile reports have demonstrated the importance of its metabolism for bone health. However, these reports have not been collated for more than 10 years. Therefore, this review focuses on taurine–bone interactions and covers recently discovered aspects of taurine’s effects on osteoblastogenesis, osteoclastogenesis, bone structure, and bone pathologies (e.g., osteoporosis and fracture healing), with due attention to the taurine–cartilage relationship. |
format | Online Article Text |
id | pubmed-9449101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94491012022-09-14 A Key Metabolic Regulator of Bone and Cartilage Health Pérez-Hernández, Elizabeth Pastrana-Carballo, Jesús Javier Gómez-Chávez, Fernando Gupta, Ramesh C. Pérez-Hernández, Nury Endocrinol Metab (Seoul) Review Article Taurine, a cysteine-derived zwitterionic sulfonic acid, is a common ingredient in energy drinks and is naturally found in fish and other seafood. In humans, taurine is produced mainly in the liver, and it can also be obtained from food. In target tissues, such as the retina, heart, and skeletal muscle, it functions as an essential antioxidant, osmolyte, and antiapoptotic agent. Taurine is also involved in energy metabolism and calcium homeostasis. Taurine plays a considerable role in bone growth and development, and high-profile reports have demonstrated the importance of its metabolism for bone health. However, these reports have not been collated for more than 10 years. Therefore, this review focuses on taurine–bone interactions and covers recently discovered aspects of taurine’s effects on osteoblastogenesis, osteoclastogenesis, bone structure, and bone pathologies (e.g., osteoporosis and fracture healing), with due attention to the taurine–cartilage relationship. Korean Endocrine Society 2022-08 2022-08-08 /pmc/articles/PMC9449101/ /pubmed/35938304 http://dx.doi.org/10.3803/EnM.2022.1443 Text en Copyright © 2022 Korean Endocrine Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pérez-Hernández, Elizabeth Pastrana-Carballo, Jesús Javier Gómez-Chávez, Fernando Gupta, Ramesh C. Pérez-Hernández, Nury A Key Metabolic Regulator of Bone and Cartilage Health |
title | A Key Metabolic Regulator of Bone and Cartilage Health |
title_full | A Key Metabolic Regulator of Bone and Cartilage Health |
title_fullStr | A Key Metabolic Regulator of Bone and Cartilage Health |
title_full_unstemmed | A Key Metabolic Regulator of Bone and Cartilage Health |
title_short | A Key Metabolic Regulator of Bone and Cartilage Health |
title_sort | key metabolic regulator of bone and cartilage health |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449101/ https://www.ncbi.nlm.nih.gov/pubmed/35938304 http://dx.doi.org/10.3803/EnM.2022.1443 |
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