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Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
BACKGROUND: The prevalence of young-onset diabetes (YOD) has been increasing worldwide. As the incidence of YOD increases, it is necessary to determine the characteristics of YOD and the factors that influence its development and associated complications. METHODS: In this retrospective study, we rec...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Endocrine Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449113/ https://www.ncbi.nlm.nih.gov/pubmed/36065646 http://dx.doi.org/10.3803/EnM.2022.1501 |
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author | Baek, Han-sang Park, Ji-Yeon Yu, Jin Lee, Joonyub Yang, Yeoree Ha, Jeonghoon Lee, Seung Hwan Cho, Jae Hyoung Lim, Dong-Jun Kim, Hun-Sung |
author_facet | Baek, Han-sang Park, Ji-Yeon Yu, Jin Lee, Joonyub Yang, Yeoree Ha, Jeonghoon Lee, Seung Hwan Cho, Jae Hyoung Lim, Dong-Jun Kim, Hun-Sung |
author_sort | Baek, Han-sang |
collection | PubMed |
description | BACKGROUND: The prevalence of young-onset diabetes (YOD) has been increasing worldwide. As the incidence of YOD increases, it is necessary to determine the characteristics of YOD and the factors that influence its development and associated complications. METHODS: In this retrospective study, we recruited patients who were diagnosed with type 2 diabetes mellitus between June 2001 and December 2021 at a tertiary hospital. The study population was categorized according to age: YOD (age <40 years), middle-age-onset diabetes (MOD, 40≤ age <65 years), and late-onset diabetes (LOD, age ≥65 years). We examined trends in glycemic control by analyzing fasting glucose levels during the first year in each age group. A Cox proportional-hazards model was used to determine the relative risk of developing complications according to glycemic control trends. RESULTS: The fasting glucose level at the time of diagnosis was highest in the YOD group (YOD 149±65 mg/dL; MOD 143±54 mg/dL; and LOD 140±55 mg/dL; P=0.009). In the YOD group, glucose levels decreased at 3 months, but increased by 12 months. YOD patients and those with poor glycemic control in the first year were at a higher risk of developing complications, whereas the risk in patients with LOD was not statistically significant. CONCLUSION: YOD patients had higher glucose levels at diagnosis, and their glycemic control was poorly maintained. As poor glycemic control can influence the development of complications, especially in young patients, intensive treatment is necessary for patients with YOD. |
format | Online Article Text |
id | pubmed-9449113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-94491132022-09-14 Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes Baek, Han-sang Park, Ji-Yeon Yu, Jin Lee, Joonyub Yang, Yeoree Ha, Jeonghoon Lee, Seung Hwan Cho, Jae Hyoung Lim, Dong-Jun Kim, Hun-Sung Endocrinol Metab (Seoul) Original Article BACKGROUND: The prevalence of young-onset diabetes (YOD) has been increasing worldwide. As the incidence of YOD increases, it is necessary to determine the characteristics of YOD and the factors that influence its development and associated complications. METHODS: In this retrospective study, we recruited patients who were diagnosed with type 2 diabetes mellitus between June 2001 and December 2021 at a tertiary hospital. The study population was categorized according to age: YOD (age <40 years), middle-age-onset diabetes (MOD, 40≤ age <65 years), and late-onset diabetes (LOD, age ≥65 years). We examined trends in glycemic control by analyzing fasting glucose levels during the first year in each age group. A Cox proportional-hazards model was used to determine the relative risk of developing complications according to glycemic control trends. RESULTS: The fasting glucose level at the time of diagnosis was highest in the YOD group (YOD 149±65 mg/dL; MOD 143±54 mg/dL; and LOD 140±55 mg/dL; P=0.009). In the YOD group, glucose levels decreased at 3 months, but increased by 12 months. YOD patients and those with poor glycemic control in the first year were at a higher risk of developing complications, whereas the risk in patients with LOD was not statistically significant. CONCLUSION: YOD patients had higher glucose levels at diagnosis, and their glycemic control was poorly maintained. As poor glycemic control can influence the development of complications, especially in young patients, intensive treatment is necessary for patients with YOD. Korean Endocrine Society 2022-08 2022-08-29 /pmc/articles/PMC9449113/ /pubmed/36065646 http://dx.doi.org/10.3803/EnM.2022.1501 Text en Copyright © 2022 Korean Endocrine Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Baek, Han-sang Park, Ji-Yeon Yu, Jin Lee, Joonyub Yang, Yeoree Ha, Jeonghoon Lee, Seung Hwan Cho, Jae Hyoung Lim, Dong-Jun Kim, Hun-Sung Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes |
title | Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes |
title_full | Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes |
title_fullStr | Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes |
title_full_unstemmed | Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes |
title_short | Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes |
title_sort | characteristics of glycemic control and long-term complications in patients with young-onset type 2 diabetes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449113/ https://www.ncbi.nlm.nih.gov/pubmed/36065646 http://dx.doi.org/10.3803/EnM.2022.1501 |
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