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Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes

BACKGROUND: The prevalence of young-onset diabetes (YOD) has been increasing worldwide. As the incidence of YOD increases, it is necessary to determine the characteristics of YOD and the factors that influence its development and associated complications. METHODS: In this retrospective study, we rec...

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Autores principales: Baek, Han-sang, Park, Ji-Yeon, Yu, Jin, Lee, Joonyub, Yang, Yeoree, Ha, Jeonghoon, Lee, Seung Hwan, Cho, Jae Hyoung, Lim, Dong-Jun, Kim, Hun-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449113/
https://www.ncbi.nlm.nih.gov/pubmed/36065646
http://dx.doi.org/10.3803/EnM.2022.1501
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author Baek, Han-sang
Park, Ji-Yeon
Yu, Jin
Lee, Joonyub
Yang, Yeoree
Ha, Jeonghoon
Lee, Seung Hwan
Cho, Jae Hyoung
Lim, Dong-Jun
Kim, Hun-Sung
author_facet Baek, Han-sang
Park, Ji-Yeon
Yu, Jin
Lee, Joonyub
Yang, Yeoree
Ha, Jeonghoon
Lee, Seung Hwan
Cho, Jae Hyoung
Lim, Dong-Jun
Kim, Hun-Sung
author_sort Baek, Han-sang
collection PubMed
description BACKGROUND: The prevalence of young-onset diabetes (YOD) has been increasing worldwide. As the incidence of YOD increases, it is necessary to determine the characteristics of YOD and the factors that influence its development and associated complications. METHODS: In this retrospective study, we recruited patients who were diagnosed with type 2 diabetes mellitus between June 2001 and December 2021 at a tertiary hospital. The study population was categorized according to age: YOD (age <40 years), middle-age-onset diabetes (MOD, 40≤ age <65 years), and late-onset diabetes (LOD, age ≥65 years). We examined trends in glycemic control by analyzing fasting glucose levels during the first year in each age group. A Cox proportional-hazards model was used to determine the relative risk of developing complications according to glycemic control trends. RESULTS: The fasting glucose level at the time of diagnosis was highest in the YOD group (YOD 149±65 mg/dL; MOD 143±54 mg/dL; and LOD 140±55 mg/dL; P=0.009). In the YOD group, glucose levels decreased at 3 months, but increased by 12 months. YOD patients and those with poor glycemic control in the first year were at a higher risk of developing complications, whereas the risk in patients with LOD was not statistically significant. CONCLUSION: YOD patients had higher glucose levels at diagnosis, and their glycemic control was poorly maintained. As poor glycemic control can influence the development of complications, especially in young patients, intensive treatment is necessary for patients with YOD.
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spelling pubmed-94491132022-09-14 Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes Baek, Han-sang Park, Ji-Yeon Yu, Jin Lee, Joonyub Yang, Yeoree Ha, Jeonghoon Lee, Seung Hwan Cho, Jae Hyoung Lim, Dong-Jun Kim, Hun-Sung Endocrinol Metab (Seoul) Original Article BACKGROUND: The prevalence of young-onset diabetes (YOD) has been increasing worldwide. As the incidence of YOD increases, it is necessary to determine the characteristics of YOD and the factors that influence its development and associated complications. METHODS: In this retrospective study, we recruited patients who were diagnosed with type 2 diabetes mellitus between June 2001 and December 2021 at a tertiary hospital. The study population was categorized according to age: YOD (age <40 years), middle-age-onset diabetes (MOD, 40≤ age <65 years), and late-onset diabetes (LOD, age ≥65 years). We examined trends in glycemic control by analyzing fasting glucose levels during the first year in each age group. A Cox proportional-hazards model was used to determine the relative risk of developing complications according to glycemic control trends. RESULTS: The fasting glucose level at the time of diagnosis was highest in the YOD group (YOD 149±65 mg/dL; MOD 143±54 mg/dL; and LOD 140±55 mg/dL; P=0.009). In the YOD group, glucose levels decreased at 3 months, but increased by 12 months. YOD patients and those with poor glycemic control in the first year were at a higher risk of developing complications, whereas the risk in patients with LOD was not statistically significant. CONCLUSION: YOD patients had higher glucose levels at diagnosis, and their glycemic control was poorly maintained. As poor glycemic control can influence the development of complications, especially in young patients, intensive treatment is necessary for patients with YOD. Korean Endocrine Society 2022-08 2022-08-29 /pmc/articles/PMC9449113/ /pubmed/36065646 http://dx.doi.org/10.3803/EnM.2022.1501 Text en Copyright © 2022 Korean Endocrine Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Baek, Han-sang
Park, Ji-Yeon
Yu, Jin
Lee, Joonyub
Yang, Yeoree
Ha, Jeonghoon
Lee, Seung Hwan
Cho, Jae Hyoung
Lim, Dong-Jun
Kim, Hun-Sung
Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
title Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
title_full Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
title_fullStr Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
title_full_unstemmed Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
title_short Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
title_sort characteristics of glycemic control and long-term complications in patients with young-onset type 2 diabetes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449113/
https://www.ncbi.nlm.nih.gov/pubmed/36065646
http://dx.doi.org/10.3803/EnM.2022.1501
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