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Craniofacial development in patients of Tessier No.0 cleft with a bifid nose using 3D computed tomography

OBJECTIVE: Considerable studies have focused mainly on the facial deformity of Tessier No.0 cleft with a bifid nose, but the deformity of the skull is not well understood. Therefore, our study aimed to explore the evolution of cranial dysmorphology and the chronology of Tessier No.0 cleft with a bif...

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Autores principales: Wang, Xin, Wang, Huan, You, Jianjun, Zheng, Ruobing, Xu, Yihao, Fan, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449123/
https://www.ncbi.nlm.nih.gov/pubmed/36090555
http://dx.doi.org/10.3389/fped.2022.979345
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author Wang, Xin
Wang, Huan
You, Jianjun
Zheng, Ruobing
Xu, Yihao
Fan, Fei
author_facet Wang, Xin
Wang, Huan
You, Jianjun
Zheng, Ruobing
Xu, Yihao
Fan, Fei
author_sort Wang, Xin
collection PubMed
description OBJECTIVE: Considerable studies have focused mainly on the facial deformity of Tessier No.0 cleft with a bifid nose, but the deformity of the skull is not well understood. Therefore, our study aimed to explore the evolution of cranial dysmorphology and the chronology of Tessier No.0 cleft with a bifid nose, by three-dimensional measurements. METHODS: Ninety-six non-surgical patients and computed tomographic scans were included (Tessier No.0 cleft with a bifid nose, n = 48; controls, n = 48) and divided into five age subgroups. Craniofacial cephalometric measurements were analyzed by Mimics software. RESULTS: The widening of nasal bone was the most remarkable and persistent from 2 years old appropriately. The overall cranial base length in patients compared with controls increased 11.8% (p < 0.01) on average. The middle and posterior cranial fossa increasing accounted for most of this change. The cranial base angles also showed increased obviously. By analyzing the linear of the nasopharynx and respiratory tract, it was found that its development did not affect respiration. CONCLUSIONS: The cranial base deformity of Tessier No.0 cleft with a bifid nose consists of the whole skull base and particularly the middle and posterior cranial base length increase. At the same time, there may be late closure of the spheno-occipital synchondrosis and sella displacement. We believe this study is unique in providing valuable data for elucidating the pathological and morphological abnormalities of skull base development in Tessier No.0 cleft with a bifid nose.
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spelling pubmed-94491232022-09-08 Craniofacial development in patients of Tessier No.0 cleft with a bifid nose using 3D computed tomography Wang, Xin Wang, Huan You, Jianjun Zheng, Ruobing Xu, Yihao Fan, Fei Front Pediatr Pediatrics OBJECTIVE: Considerable studies have focused mainly on the facial deformity of Tessier No.0 cleft with a bifid nose, but the deformity of the skull is not well understood. Therefore, our study aimed to explore the evolution of cranial dysmorphology and the chronology of Tessier No.0 cleft with a bifid nose, by three-dimensional measurements. METHODS: Ninety-six non-surgical patients and computed tomographic scans were included (Tessier No.0 cleft with a bifid nose, n = 48; controls, n = 48) and divided into five age subgroups. Craniofacial cephalometric measurements were analyzed by Mimics software. RESULTS: The widening of nasal bone was the most remarkable and persistent from 2 years old appropriately. The overall cranial base length in patients compared with controls increased 11.8% (p < 0.01) on average. The middle and posterior cranial fossa increasing accounted for most of this change. The cranial base angles also showed increased obviously. By analyzing the linear of the nasopharynx and respiratory tract, it was found that its development did not affect respiration. CONCLUSIONS: The cranial base deformity of Tessier No.0 cleft with a bifid nose consists of the whole skull base and particularly the middle and posterior cranial base length increase. At the same time, there may be late closure of the spheno-occipital synchondrosis and sella displacement. We believe this study is unique in providing valuable data for elucidating the pathological and morphological abnormalities of skull base development in Tessier No.0 cleft with a bifid nose. Frontiers Media S.A. 2022-08-24 /pmc/articles/PMC9449123/ /pubmed/36090555 http://dx.doi.org/10.3389/fped.2022.979345 Text en Copyright © 2022 Wang, Wang, You, Zheng, Xu and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Wang, Xin
Wang, Huan
You, Jianjun
Zheng, Ruobing
Xu, Yihao
Fan, Fei
Craniofacial development in patients of Tessier No.0 cleft with a bifid nose using 3D computed tomography
title Craniofacial development in patients of Tessier No.0 cleft with a bifid nose using 3D computed tomography
title_full Craniofacial development in patients of Tessier No.0 cleft with a bifid nose using 3D computed tomography
title_fullStr Craniofacial development in patients of Tessier No.0 cleft with a bifid nose using 3D computed tomography
title_full_unstemmed Craniofacial development in patients of Tessier No.0 cleft with a bifid nose using 3D computed tomography
title_short Craniofacial development in patients of Tessier No.0 cleft with a bifid nose using 3D computed tomography
title_sort craniofacial development in patients of tessier no.0 cleft with a bifid nose using 3d computed tomography
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449123/
https://www.ncbi.nlm.nih.gov/pubmed/36090555
http://dx.doi.org/10.3389/fped.2022.979345
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