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Puerarin: A protective drug against ischemia-reperfusion injury
Ischemia-reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body and is frequently associated with severe cellular damage and death. Puerarin is an isoflavone compound extracted from the root of Pueraria lobata and has pharmacological effects such as dila...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449408/ https://www.ncbi.nlm.nih.gov/pubmed/36091830 http://dx.doi.org/10.3389/fphar.2022.927611 |
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author | Gao, Minglang Zhang, Ziyao Lai, Kai Deng, Yu Zhao, Chuanbing Lu, Zilong Geng, Qing |
author_facet | Gao, Minglang Zhang, Ziyao Lai, Kai Deng, Yu Zhao, Chuanbing Lu, Zilong Geng, Qing |
author_sort | Gao, Minglang |
collection | PubMed |
description | Ischemia-reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body and is frequently associated with severe cellular damage and death. Puerarin is an isoflavone compound extracted from the root of Pueraria lobata and has pharmacological effects such as dilating cerebral vessels and anti-free radical generation in cerebral ischemic tissues. With the deepening of experimental research and clinical research on puerarin, it has been found that puerarin has a protective effect on ischemia-reperfusion injury (IRI) of the heart, brain, spinal cord, lung, intestine and other organs. In summary, puerarin has a vast range of pharmacological effects and significant protective effects, and it also has obvious advantages in the clinical protection of patients with organ IRI. With the deepening of experimental pharmacological research and clinical research, it is expected to be an effective drug for IRI treatment. In this review, we summarize the current knowledge of the protective effect of puerarin on I/R organ injury and its possible underlying molecular mechanisms. |
format | Online Article Text |
id | pubmed-9449408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94494082022-09-08 Puerarin: A protective drug against ischemia-reperfusion injury Gao, Minglang Zhang, Ziyao Lai, Kai Deng, Yu Zhao, Chuanbing Lu, Zilong Geng, Qing Front Pharmacol Pharmacology Ischemia-reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body and is frequently associated with severe cellular damage and death. Puerarin is an isoflavone compound extracted from the root of Pueraria lobata and has pharmacological effects such as dilating cerebral vessels and anti-free radical generation in cerebral ischemic tissues. With the deepening of experimental research and clinical research on puerarin, it has been found that puerarin has a protective effect on ischemia-reperfusion injury (IRI) of the heart, brain, spinal cord, lung, intestine and other organs. In summary, puerarin has a vast range of pharmacological effects and significant protective effects, and it also has obvious advantages in the clinical protection of patients with organ IRI. With the deepening of experimental pharmacological research and clinical research, it is expected to be an effective drug for IRI treatment. In this review, we summarize the current knowledge of the protective effect of puerarin on I/R organ injury and its possible underlying molecular mechanisms. Frontiers Media S.A. 2022-08-24 /pmc/articles/PMC9449408/ /pubmed/36091830 http://dx.doi.org/10.3389/fphar.2022.927611 Text en Copyright © 2022 Gao, Zhang, Lai, Deng, Zhao, Lu and Geng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Gao, Minglang Zhang, Ziyao Lai, Kai Deng, Yu Zhao, Chuanbing Lu, Zilong Geng, Qing Puerarin: A protective drug against ischemia-reperfusion injury |
title | Puerarin: A protective drug against ischemia-reperfusion injury |
title_full | Puerarin: A protective drug against ischemia-reperfusion injury |
title_fullStr | Puerarin: A protective drug against ischemia-reperfusion injury |
title_full_unstemmed | Puerarin: A protective drug against ischemia-reperfusion injury |
title_short | Puerarin: A protective drug against ischemia-reperfusion injury |
title_sort | puerarin: a protective drug against ischemia-reperfusion injury |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449408/ https://www.ncbi.nlm.nih.gov/pubmed/36091830 http://dx.doi.org/10.3389/fphar.2022.927611 |
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