Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances

Breast cancer (BC) is the most common malignancy among females worldwide, and high resistance to drugs and metastasis rates are the leading causes of death in BC patients. Releasing anti-cancer drugs precisely to the tumor site can improve the efficacy and reduce the side effects on the body. Natura...

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Autores principales: Jia, Yufeng, Chen, Siwen, Wang, Chenyu, Sun, Tao, Yang, Liqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449492/
https://www.ncbi.nlm.nih.gov/pubmed/36091467
http://dx.doi.org/10.3389/fbioe.2022.990145
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author Jia, Yufeng
Chen, Siwen
Wang, Chenyu
Sun, Tao
Yang, Liqun
author_facet Jia, Yufeng
Chen, Siwen
Wang, Chenyu
Sun, Tao
Yang, Liqun
author_sort Jia, Yufeng
collection PubMed
description Breast cancer (BC) is the most common malignancy among females worldwide, and high resistance to drugs and metastasis rates are the leading causes of death in BC patients. Releasing anti-cancer drugs precisely to the tumor site can improve the efficacy and reduce the side effects on the body. Natural polymers are attracting extensive interest as drug carriers in treating breast cancer. Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility, biodegradability, and non-immunogenicity and is a significant component of the extracellular matrix. The CD44 receptor of HA is overexpressed in breast cancer cells and can be targeted to breast tumors. Therefore, many researchers have developed nano drug delivery systems (NDDS) based on the CD44 receptor tumor-targeting properties of HA. This review examines the application of HA in NDDSs for breast cancer in recent years. Based on the structural composition of NDDSs, they are divided into HA NDDSs, Modified HA NDDSs, and HA hybrid NDDSs.
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spelling pubmed-94494922022-09-08 Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances Jia, Yufeng Chen, Siwen Wang, Chenyu Sun, Tao Yang, Liqun Front Bioeng Biotechnol Bioengineering and Biotechnology Breast cancer (BC) is the most common malignancy among females worldwide, and high resistance to drugs and metastasis rates are the leading causes of death in BC patients. Releasing anti-cancer drugs precisely to the tumor site can improve the efficacy and reduce the side effects on the body. Natural polymers are attracting extensive interest as drug carriers in treating breast cancer. Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility, biodegradability, and non-immunogenicity and is a significant component of the extracellular matrix. The CD44 receptor of HA is overexpressed in breast cancer cells and can be targeted to breast tumors. Therefore, many researchers have developed nano drug delivery systems (NDDS) based on the CD44 receptor tumor-targeting properties of HA. This review examines the application of HA in NDDSs for breast cancer in recent years. Based on the structural composition of NDDSs, they are divided into HA NDDSs, Modified HA NDDSs, and HA hybrid NDDSs. Frontiers Media S.A. 2022-08-24 /pmc/articles/PMC9449492/ /pubmed/36091467 http://dx.doi.org/10.3389/fbioe.2022.990145 Text en Copyright © 2022 Jia, Chen, Wang, Sun and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Jia, Yufeng
Chen, Siwen
Wang, Chenyu
Sun, Tao
Yang, Liqun
Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances
title Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances
title_full Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances
title_fullStr Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances
title_full_unstemmed Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances
title_short Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances
title_sort hyaluronic acid-based nano drug delivery systems for breast cancer treatment: recent advances
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449492/
https://www.ncbi.nlm.nih.gov/pubmed/36091467
http://dx.doi.org/10.3389/fbioe.2022.990145
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