Innatus immunis: Evolving paradigm of adaptive NK cells

The mechanisms that govern the development of adaptive-like NK cells are elusive. Shemesh et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220551) report that the development of FcRγ(−/low) adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α. These findings pr...

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Detalles Bibliográficos
Autores principales: Khalil, Mohamed, Malarkannan, Subramaniam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449531/
https://www.ncbi.nlm.nih.gov/pubmed/36066493
http://dx.doi.org/10.1084/jem.20221254
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author Khalil, Mohamed
Malarkannan, Subramaniam
author_facet Khalil, Mohamed
Malarkannan, Subramaniam
author_sort Khalil, Mohamed
collection PubMed
description The mechanisms that govern the development of adaptive-like NK cells are elusive. Shemesh et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220551) report that the development of FcRγ(−/low) adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α. These findings provide exciting new molecular blueprints explaining the development and functions of adaptive-like NK cells.
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spelling pubmed-94495312023-03-06 Innatus immunis: Evolving paradigm of adaptive NK cells Khalil, Mohamed Malarkannan, Subramaniam J Exp Med Insights The mechanisms that govern the development of adaptive-like NK cells are elusive. Shemesh et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220551) report that the development of FcRγ(−/low) adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α. These findings provide exciting new molecular blueprints explaining the development and functions of adaptive-like NK cells. Rockefeller University Press 2022-09-06 /pmc/articles/PMC9449531/ /pubmed/36066493 http://dx.doi.org/10.1084/jem.20221254 Text en © 2022 Khalil and Malarkannan https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Khalil, Mohamed
Malarkannan, Subramaniam
Innatus immunis: Evolving paradigm of adaptive NK cells
title Innatus immunis: Evolving paradigm of adaptive NK cells
title_full Innatus immunis: Evolving paradigm of adaptive NK cells
title_fullStr Innatus immunis: Evolving paradigm of adaptive NK cells
title_full_unstemmed Innatus immunis: Evolving paradigm of adaptive NK cells
title_short Innatus immunis: Evolving paradigm of adaptive NK cells
title_sort innatus immunis: evolving paradigm of adaptive nk cells
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449531/
https://www.ncbi.nlm.nih.gov/pubmed/36066493
http://dx.doi.org/10.1084/jem.20221254
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