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Targeting thymidine phosphorylase alleviates resistance to dendritic cell immunotherapy in colorectal cancer and promotes antitumor immunity

T-cell exhaustion plays a pivotal role in the resistance of microsatellite-stable colorectal cancer (CRC) to immunotherapy. Identifying and targeting T-cell exhaustion-activating mechanisms is a promising strategy to augment the effects of immunotherapy. Here, we found that thymidine phosphorylase (...

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Detalles Bibliográficos
Autores principales:	Paladhi, Ankush, Daripa, Samrat, Mondal, Indrani, Hira, Sumit Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449540/ https://www.ncbi.nlm.nih.gov/pubmed/36090972 http://dx.doi.org/10.3389/fimmu.2022.988071

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