Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and pro...

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Detalles Bibliográficos
Autores principales: Zou, Yuheng, Zhang, Hongying, Bi, Feng, Tang, Qiulin, Xu, Huanji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449579/
https://www.ncbi.nlm.nih.gov/pubmed/36091156
http://dx.doi.org/10.3389/fonc.2022.938502
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author Zou, Yuheng
Zhang, Hongying
Bi, Feng
Tang, Qiulin
Xu, Huanji
author_facet Zou, Yuheng
Zhang, Hongying
Bi, Feng
Tang, Qiulin
Xu, Huanji
author_sort Zou, Yuheng
collection PubMed
description Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and progression and is a promising therapeutic target for cancer treatment. In this review, we provide an overview of the role and regulation of SQLE in cancer and summarize the updates of antitumor therapy targeting SQLE.
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spelling pubmed-94495792022-09-08 Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy Zou, Yuheng Zhang, Hongying Bi, Feng Tang, Qiulin Xu, Huanji Front Oncol Oncology Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and progression and is a promising therapeutic target for cancer treatment. In this review, we provide an overview of the role and regulation of SQLE in cancer and summarize the updates of antitumor therapy targeting SQLE. Frontiers Media S.A. 2022-08-24 /pmc/articles/PMC9449579/ /pubmed/36091156 http://dx.doi.org/10.3389/fonc.2022.938502 Text en Copyright © 2022 Zou, Zhang, Bi, Tang and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zou, Yuheng
Zhang, Hongying
Bi, Feng
Tang, Qiulin
Xu, Huanji
Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
title Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
title_full Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
title_fullStr Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
title_full_unstemmed Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
title_short Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
title_sort targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449579/
https://www.ncbi.nlm.nih.gov/pubmed/36091156
http://dx.doi.org/10.3389/fonc.2022.938502
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