Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and pro...

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Detalles Bibliográficos
Autores principales: Zou, Yuheng, Zhang, Hongying, Bi, Feng, Tang, Qiulin, Xu, Huanji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449579/
https://www.ncbi.nlm.nih.gov/pubmed/36091156
http://dx.doi.org/10.3389/fonc.2022.938502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449579/
https://www.ncbi.nlm.nih.gov/pubmed/36091156
http://dx.doi.org/10.3389/fonc.2022.938502

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