Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells

FBXW7 is one of the most frequently mutated tumor suppressors, deficiency of which has been associated with resistance to some anticancer therapies. Through bioinformatics and genome‐wide CRISPR screens, we here reveal that FBXW7 deficiency leads to multidrug resistance (MDR). Proteomic analyses fou...

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Detalles Bibliográficos
Autores principales: Sanchez‐Burgos, Laura, Navarro‐González, Belén, García‐Martín, Santiago, Sirozh, Oleksandra, Mota‐Pino, Jorge, Fueyo‐Marcos, Elena, Tejero, Héctor, Antón, Marta Elena, Murga, Matilde, Al‐Shahrour, Fátima, Fernandez‐Capetillo, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449593/
https://www.ncbi.nlm.nih.gov/pubmed/35861150
http://dx.doi.org/10.15252/emmm.202215855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449593/
https://www.ncbi.nlm.nih.gov/pubmed/35861150
http://dx.doi.org/10.15252/emmm.202215855

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