Pembrolizumab-induced Focal Pancreatitis Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration

A 69-year-old man with advanced non-small-cell lung cancer was treated with pembrolizumab for 4 months. Three months after pembrolizumab was discontinued, computed tomography showed enlargement of the pancreatic head, with hypoattenuating areas in the pancreatic head to body. On endoscopic ultrasono...

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Autores principales: Ikemoto, Juri, Ishii, Yasutaka, Serikawa, Masahiro, Tsuboi, Tomofumi, Tsushima, Ken, Nakamura, Shinya, Hirano, Tetsuro, Kiyoshita, Yusuke, Saeki, Sho, Tamura, Yosuke, Miyamoto, Sayaka, Nakamura, Kazuki, Furukawa, Masaru, Arihiro, Koji, Aikata, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449604/
https://www.ncbi.nlm.nih.gov/pubmed/35022344
http://dx.doi.org/10.2169/internalmedicine.8507-21
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author Ikemoto, Juri
Ishii, Yasutaka
Serikawa, Masahiro
Tsuboi, Tomofumi
Tsushima, Ken
Nakamura, Shinya
Hirano, Tetsuro
Kiyoshita, Yusuke
Saeki, Sho
Tamura, Yosuke
Miyamoto, Sayaka
Nakamura, Kazuki
Furukawa, Masaru
Arihiro, Koji
Aikata, Hiroshi
author_facet Ikemoto, Juri
Ishii, Yasutaka
Serikawa, Masahiro
Tsuboi, Tomofumi
Tsushima, Ken
Nakamura, Shinya
Hirano, Tetsuro
Kiyoshita, Yusuke
Saeki, Sho
Tamura, Yosuke
Miyamoto, Sayaka
Nakamura, Kazuki
Furukawa, Masaru
Arihiro, Koji
Aikata, Hiroshi
author_sort Ikemoto, Juri
collection PubMed
description A 69-year-old man with advanced non-small-cell lung cancer was treated with pembrolizumab for 4 months. Three months after pembrolizumab was discontinued, computed tomography showed enlargement of the pancreatic head, with hypoattenuating areas in the pancreatic head to body. On endoscopic ultrasonography, the entire pancreatic parenchyma was hypoechoic. Endoscopic retrograde cholangiopancreatography showed narrowing of the main pancreatic duct at the pancreatic head. Endoscopic ultrasound-guided fine-needle aspiration showed inflammatory cell infiltration in the stroma but no neoplastic lesions. CD8-positve T cells were dominant over CD4-positive T cells in the infiltrating lymphocytes, and the patient was diagnosed with pembrolizumab-induced pancreatitis.
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spelling pubmed-94496042022-09-19 Pembrolizumab-induced Focal Pancreatitis Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration Ikemoto, Juri Ishii, Yasutaka Serikawa, Masahiro Tsuboi, Tomofumi Tsushima, Ken Nakamura, Shinya Hirano, Tetsuro Kiyoshita, Yusuke Saeki, Sho Tamura, Yosuke Miyamoto, Sayaka Nakamura, Kazuki Furukawa, Masaru Arihiro, Koji Aikata, Hiroshi Intern Med Case Report A 69-year-old man with advanced non-small-cell lung cancer was treated with pembrolizumab for 4 months. Three months after pembrolizumab was discontinued, computed tomography showed enlargement of the pancreatic head, with hypoattenuating areas in the pancreatic head to body. On endoscopic ultrasonography, the entire pancreatic parenchyma was hypoechoic. Endoscopic retrograde cholangiopancreatography showed narrowing of the main pancreatic duct at the pancreatic head. Endoscopic ultrasound-guided fine-needle aspiration showed inflammatory cell infiltration in the stroma but no neoplastic lesions. CD8-positve T cells were dominant over CD4-positive T cells in the infiltrating lymphocytes, and the patient was diagnosed with pembrolizumab-induced pancreatitis. The Japanese Society of Internal Medicine 2022-01-13 2022-08-15 /pmc/articles/PMC9449604/ /pubmed/35022344 http://dx.doi.org/10.2169/internalmedicine.8507-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ikemoto, Juri
Ishii, Yasutaka
Serikawa, Masahiro
Tsuboi, Tomofumi
Tsushima, Ken
Nakamura, Shinya
Hirano, Tetsuro
Kiyoshita, Yusuke
Saeki, Sho
Tamura, Yosuke
Miyamoto, Sayaka
Nakamura, Kazuki
Furukawa, Masaru
Arihiro, Koji
Aikata, Hiroshi
Pembrolizumab-induced Focal Pancreatitis Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration
title Pembrolizumab-induced Focal Pancreatitis Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration
title_full Pembrolizumab-induced Focal Pancreatitis Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration
title_fullStr Pembrolizumab-induced Focal Pancreatitis Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration
title_full_unstemmed Pembrolizumab-induced Focal Pancreatitis Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration
title_short Pembrolizumab-induced Focal Pancreatitis Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration
title_sort pembrolizumab-induced focal pancreatitis diagnosed by endoscopic ultrasound-guided fine-needle aspiration
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449604/
https://www.ncbi.nlm.nih.gov/pubmed/35022344
http://dx.doi.org/10.2169/internalmedicine.8507-21
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