Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma

An 82-year-old man was transferred to our hospital due to impaired consciousness. His albumin-corrected calcium level was 14.2 mg/dL, intact parathyroid hormone (PTH) and PTH-related protein levels were reduced, and his 1,25-dihydroxyvitamin D [1,25(OH)(2)VitD] level was elevated at 71.5 pg/mL. Comp...

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Autores principales: Ogawa, Masashi, Morikawa, Maho, Kobatake, Masaki, Murakami, Taku, Yamamoto, Yuki, Watanabe, Rikiya, Yamada, Katsumi, Nishiyama, Katsuhito, Yasutomo, Yoshiro, Hara, Kenta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449614/
https://www.ncbi.nlm.nih.gov/pubmed/35965075
http://dx.doi.org/10.2169/internalmedicine.8933-21
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author Ogawa, Masashi
Morikawa, Maho
Kobatake, Masaki
Murakami, Taku
Yamamoto, Yuki
Watanabe, Rikiya
Yamada, Katsumi
Nishiyama, Katsuhito
Yasutomo, Yoshiro
Hara, Kenta
author_facet Ogawa, Masashi
Morikawa, Maho
Kobatake, Masaki
Murakami, Taku
Yamamoto, Yuki
Watanabe, Rikiya
Yamada, Katsumi
Nishiyama, Katsuhito
Yasutomo, Yoshiro
Hara, Kenta
author_sort Ogawa, Masashi
collection PubMed
description An 82-year-old man was transferred to our hospital due to impaired consciousness. His albumin-corrected calcium level was 14.2 mg/dL, intact parathyroid hormone (PTH) and PTH-related protein levels were reduced, and his 1,25-dihydroxyvitamin D [1,25(OH)(2)VitD] level was elevated at 71.5 pg/mL. Computed tomography revealed masses on the bilateral ribs. The mass on the rib was biopsied and diagnosed as diffuse large B-cell lymphoma (DLBCL). Immunostaining of the biopsy sample with the anti-CYP27B1 antibody revealed the ectopic expression of 1α-hydroxylase in the lesion. We herein report a rare case of hypercalcemia induced by the overproduction of 1,25(OH)(2)VitD in DLBCL ectopically expressing 1α-hydroxylase.
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spelling pubmed-94496142022-09-19 Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma Ogawa, Masashi Morikawa, Maho Kobatake, Masaki Murakami, Taku Yamamoto, Yuki Watanabe, Rikiya Yamada, Katsumi Nishiyama, Katsuhito Yasutomo, Yoshiro Hara, Kenta Intern Med Case Report An 82-year-old man was transferred to our hospital due to impaired consciousness. His albumin-corrected calcium level was 14.2 mg/dL, intact parathyroid hormone (PTH) and PTH-related protein levels were reduced, and his 1,25-dihydroxyvitamin D [1,25(OH)(2)VitD] level was elevated at 71.5 pg/mL. Computed tomography revealed masses on the bilateral ribs. The mass on the rib was biopsied and diagnosed as diffuse large B-cell lymphoma (DLBCL). Immunostaining of the biopsy sample with the anti-CYP27B1 antibody revealed the ectopic expression of 1α-hydroxylase in the lesion. We herein report a rare case of hypercalcemia induced by the overproduction of 1,25(OH)(2)VitD in DLBCL ectopically expressing 1α-hydroxylase. The Japanese Society of Internal Medicine 2022-08-15 2022-08-15 /pmc/articles/PMC9449614/ /pubmed/35965075 http://dx.doi.org/10.2169/internalmedicine.8933-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ogawa, Masashi
Morikawa, Maho
Kobatake, Masaki
Murakami, Taku
Yamamoto, Yuki
Watanabe, Rikiya
Yamada, Katsumi
Nishiyama, Katsuhito
Yasutomo, Yoshiro
Hara, Kenta
Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma
title Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma
title_full Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma
title_fullStr Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma
title_full_unstemmed Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma
title_short Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma
title_sort hypercalcemia associated with the ectopic expression of 25-hydroxyvitamin d3-1α-hydroxylase in diffuse large b-cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449614/
https://www.ncbi.nlm.nih.gov/pubmed/35965075
http://dx.doi.org/10.2169/internalmedicine.8933-21
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