Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma Associated with Nephrotic Syndrome during Hemodialysis, Treated Successfully with Tirabrutinib

A 74-year-old woman was diagnosed with Waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) in X-18. Fludarabine plus rituximab (FR) was started, and she showed remission. In July X-7, the serum creatinine (Cr) level increased to 1.67 mg/dL, and bendamustine plus rituximab (BR) was star...

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Autores principales: Sekiguchi, Yasunobu, Nishimura, You, Kanda, Hiroaki, Kawamura, Machiko, Kobayashi, Kazuhiko, Kobayashi, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449620/
https://www.ncbi.nlm.nih.gov/pubmed/35110483
http://dx.doi.org/10.2169/internalmedicine.8760-21
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author Sekiguchi, Yasunobu
Nishimura, You
Kanda, Hiroaki
Kawamura, Machiko
Kobayashi, Kazuhiko
Kobayashi, Hirofumi
author_facet Sekiguchi, Yasunobu
Nishimura, You
Kanda, Hiroaki
Kawamura, Machiko
Kobayashi, Kazuhiko
Kobayashi, Hirofumi
author_sort Sekiguchi, Yasunobu
collection PubMed
description A 74-year-old woman was diagnosed with Waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) in X-18. Fludarabine plus rituximab (FR) was started, and she showed remission. In July X-7, the serum creatinine (Cr) level increased to 1.67 mg/dL, and bendamustine plus rituximab (BR) was started. By November X-7, the Cr level had increased to 8.41 mg/dL, so she was started on hemodialysis (HD). In September X-1, she developed nephrotic syndrome. She was started on tirabrutinib at 480 mg. In July X, her nephrotic syndrome had improved, and a complete response (CR) was achieved. This is the first case of the administration of tirabrutinib in a patient undergoing HD.
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spelling pubmed-94496202022-09-19 Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma Associated with Nephrotic Syndrome during Hemodialysis, Treated Successfully with Tirabrutinib Sekiguchi, Yasunobu Nishimura, You Kanda, Hiroaki Kawamura, Machiko Kobayashi, Kazuhiko Kobayashi, Hirofumi Intern Med Case Report A 74-year-old woman was diagnosed with Waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) in X-18. Fludarabine plus rituximab (FR) was started, and she showed remission. In July X-7, the serum creatinine (Cr) level increased to 1.67 mg/dL, and bendamustine plus rituximab (BR) was started. By November X-7, the Cr level had increased to 8.41 mg/dL, so she was started on hemodialysis (HD). In September X-1, she developed nephrotic syndrome. She was started on tirabrutinib at 480 mg. In July X, her nephrotic syndrome had improved, and a complete response (CR) was achieved. This is the first case of the administration of tirabrutinib in a patient undergoing HD. The Japanese Society of Internal Medicine 2022-02-01 2022-08-15 /pmc/articles/PMC9449620/ /pubmed/35110483 http://dx.doi.org/10.2169/internalmedicine.8760-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sekiguchi, Yasunobu
Nishimura, You
Kanda, Hiroaki
Kawamura, Machiko
Kobayashi, Kazuhiko
Kobayashi, Hirofumi
Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma Associated with Nephrotic Syndrome during Hemodialysis, Treated Successfully with Tirabrutinib
title Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma Associated with Nephrotic Syndrome during Hemodialysis, Treated Successfully with Tirabrutinib
title_full Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma Associated with Nephrotic Syndrome during Hemodialysis, Treated Successfully with Tirabrutinib
title_fullStr Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma Associated with Nephrotic Syndrome during Hemodialysis, Treated Successfully with Tirabrutinib
title_full_unstemmed Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma Associated with Nephrotic Syndrome during Hemodialysis, Treated Successfully with Tirabrutinib
title_short Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma Associated with Nephrotic Syndrome during Hemodialysis, Treated Successfully with Tirabrutinib
title_sort waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma associated with nephrotic syndrome during hemodialysis, treated successfully with tirabrutinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449620/
https://www.ncbi.nlm.nih.gov/pubmed/35110483
http://dx.doi.org/10.2169/internalmedicine.8760-21
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