Two types of peptides derived from the neurotoxin GsMTx4 inhibit a mechanosensitive potassium channel by modifying the mechanogate

Atrial fibrillation is the most common sustained cardiac arrhythmia in humans. Current atrial fibrillation antiarrhythmic drugs have limited efficacy and carry the risk of ventricular proarrhythmia. GsMTx4, a mechanosensitive channel–selective inhibitor, has been shown to suppress arrhythmias throug...

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Detalles Bibliográficos
Autores principales: Zhou, Nan, Li, Hui, Xu, Jie, Shen, Zhong-Shan, Tang, Mingxi, Wang, Xiao-Hui, Su, Wan-Xin, Sokabe, Masahiro, Zhang, Zhe, Tang, Qiong-Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449670/
https://www.ncbi.nlm.nih.gov/pubmed/35933015
http://dx.doi.org/10.1016/j.jbc.2022.102326

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