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Fission yeast Dap1 heme iron-coordinating residue Y83 is required for cytochromes P450 function

Fission yeast Dap1 is a heme binding protein required for cytochromes P450 activity. Here, we tested whether Dap1 axial coordination of heme iron is required for its role in the function of the cytochrome P450 enzymes, Erg5 and Erg11. Two different dap1 mutants predicted to alter iron coordination f...

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Detalles Bibliográficos
Autores principales: Zhao, Shan, Hughes, Adam L, Espenshade, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449707/
https://www.ncbi.nlm.nih.gov/pubmed/36090151
http://dx.doi.org/10.17912/micropub.biology.000631