Effects of Insulin-Like Growth Factor (IGF-1) in Patients with Sensorineural Hearing Loss

OBJECTIVES: (1) To test the effect of local administration of insulin-like growth factor-1 (IGF-1) in patients with sensorineural hearing loss (SNHL). (2) To test the effect of local administration of IGF-1 in patients with ototoxicity. METHODS: Forty patients with SNHL were included in the study. T...

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Detalles Bibliográficos
Autores principales: Dave, Varun Jitendra, Joshi, Anagha, Bradoo, Renuka, Prajapati, Manish, Shah, Kshitij
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Academy of Otology and Neurotology and the Politzer Society 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449904/
https://www.ncbi.nlm.nih.gov/pubmed/34100744
http://dx.doi.org/10.5152/iao.2021.8549
Descripción
Sumario:OBJECTIVES: (1) To test the effect of local administration of insulin-like growth factor-1 (IGF-1) in patients with sensorineural hearing loss (SNHL). (2) To test the effect of local administration of IGF-1 in patients with ototoxicity. METHODS: Forty patients with SNHL were included in the study. Their hearing thresholds at different frequencies (0.5, 1, 2, and 4 kHz) along with the average hearing threshold were noted. The patients were then randomly allocated to 2 groups and were treated with IGF-1 via one of the following routes: (1) intratympanic injection and (2) Gelfoam.

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